{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:23:00Z","timestamp":1791141780079,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["227\u20102015"],"award-info":[{"award-number":["227\u20102015"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper\u20102 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)\u20106, IL\u20105, and IL\u20104 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient\u2010reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile\u201014 [OHIP\u201014]), pSS classification criteria and presence of extraglandular manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A case\u2010control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high\u2010sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out questionnaires. The Mann\u2010Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test, chi\u2010squared test, and Spearman correlation test were used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Interleukin\u20106 was significantly higher in pSS patients than in HCs (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0001). IL\u20106 was significantly higher in pSS patients with a positive salivary gland biopsy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04), whole stimulated saliva hyposalivation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02), and presence of musculoskeletal disorders (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03). There was a non\u2010significant positive correlation between IL\u20106 levels and PROMs for xerostomia (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.31;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.06) and OHIP\u201014 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.07;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.68) in pSS patients. Levels of IL\u20104 and IL\u20105 were not detected in both pSS and HCs patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salivary IL\u20106 levels are significantly associated with pSS patients, and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow\u2010up of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13070","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T05:21:32Z","timestamp":1592198492000},"page":"940-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of salivary inflammatory biomarkers with primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"49","author":[{"given":"Luz A.","family":"Moreno\u2010Quispe","sequence":"first","affiliation":[{"name":"Department of Dental Clinical Specialties School of Dentistry Complutense University Madrid Spain"},{"name":"Universidad Nacional de Frontera Piura Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Virto","sequence":"additional","affiliation":[{"name":"Researcher, Etiology and Therapy of Periodontal Diseases (ETEP) Research Group Complutense University and Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Fern\u00e1ndez\u2010Castro","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital Puerta de Hierro Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0920","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"L\u00f3pez\u2010Pintor","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties ORALMED Research Group School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"179","article-title":"One year in review 2017: primary Sjogren's syndrome","volume":"35","author":"Ferro F","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"118","key":"e_1_2_9_3_1","first-page":"S3","article-title":"One year in review 2019: Sj\u00f6gren's syndrome","volume":"37","author":"Cafaro G","year":"2019","journal-title":"Clin Exp 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