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In this review, we focus on molecular mechanisms of pain resulting from injury to the peripheral branch of the trigeminal nerve. This syndrome has been termed painful traumatic trigeminal neuropathy (PTTN) by the International Headache Society and replaces previous terms including atypical odontalgia, deafferentation pain, traumatic neuropathy and phantom toothache. We emphasize the scientific evidence supporting the events purported to lead to PTTN by reviewing the pathophysiology of PTTN based on relevant animal models. Additionally, we briefly overview clinical correlates and pathophysiological manifestations of PTTN.<\/jats:p>","DOI":"10.1111\/jop.13078","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T20:25:29Z","timestamp":1592511929000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular mechanisms of painful traumatic trigeminal neuropathy\u2014Evidence from animal research and clinical correlates"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-794X","authenticated-orcid":false,"given":"Olga A.","family":"Korczeniewska","sequence":"first","affiliation":[{"name":"Center for Orofacial Pain and Temporomandibular Disorders Department of Diagnostic Sciences, Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark New Jersey 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