{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:32:44Z","timestamp":1778049164470,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a relatively common inflammatory disease, with unclear etiology. A number of studies have linked Epstein\u2010Barr virus (EBV) with OLP. The present systematic review and meta\u2010analysis aimed to evaluate the available evidence regarding the potential association between EBV and OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Online databases (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched from date of inception till May 2020. Studies were included if they met the following criteria: 1) observational studies that assessed the relationship between EBV and OLP, 2) the study comprised OLP patients and control subjects, 3) diagnosis of OLP was confirmed histopathologically, and 4) articles were in English. Studies without control groups, experimental studies, case reports, and reviews were excluded. The fixed\u2010effects model was performed for meta\u2010analyses using RevMan 5.3 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10 studies comprising 386 OLP cases and 304 controls were included. Of these, only 8 studies were eligible for the meta\u2010analysis. The results of the quality assessment showed that only 2 studies were of high quality, while the remaining studies were of moderate quality. The results of the pooled eight studies revealed a significant positive association between EBV and OLP (OR\u00a0=\u00a04.41, 95% CI: [2.74, 7.11],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of the present systematic review suggest that EBV infection is statistically associated with increased risk of OLP. However, these results are preliminary, and high\u2010quality, large\u2010scale studies are warranted to further explore the potential role of EBV in the pathogenesis of OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13093","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T17:17:51Z","timestamp":1596475071000},"page":"969-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The association between Epstein\u2010Barr virus and oral lichen planus: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"49","author":[{"given":"Sajna","family":"Ashraf","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences AlFarabi Colleges of Dentistry and Nursing  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-1377","authenticated-orcid":false,"given":"Sadeq A.","family":"Al\u2010Maweri","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences AlFarabi Colleges of Dentistry and Nursing  Riyadh Saudi Arabia"},{"name":"Department of Oral Medicine Oral Pathology and Oral Radiology Faculty of Dentistry Sana\u2019a University  Yemen Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-9406","authenticated-orcid":false,"given":"Nader","family":"Alaizari","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences AlFarabi Colleges of Dentistry and Nursing  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Umair","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences AlFarabi Colleges of Dentistry and Nursing  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaihan","family":"Ariffin","sequence":"additional","affiliation":[{"name":"Prosthodontics Unit School of Dental Sciences Universiti Sains Malaysia Heath Campus  Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed N.","family":"Alhajj","sequence":"additional","affiliation":[{"name":"Prosthodontics Unit School of Dental Sciences Universiti Sains Malaysia Heath Campus  Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Kassim","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences Taibah University Dental College &amp; Hospital  Al\u2010Madinah Al\u2010Munawwarah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-7455","authenticated-orcid":false,"given":"Kamran Habib","family":"Awan","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Roseman University of Health Sciences South Jordan  Utah Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3797"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"key":"e_1_2_10_4_1","first-page":"e1109","article-title":"Clinicopathologic data of individuals with oral lichen planus: A Brazilian case series","volume":"11","author":"Lima SL","year":"2019","journal-title":"J Clin Exp Dent"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12305"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.12.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.07.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12684"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2233-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12898"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12382"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00330"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1996.tb00212.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16.e170"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2009.00660.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.124462"},{"key":"e_1_2_10_18_1","article-title":"EVIDENCE OF EPSTEIN\u2010BARR VIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: A REVIEW","volume":"82","author":"Prabhu SR","year":"2016","journal-title":"Journal (Canadian Dental Association)"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-015-0037-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235861"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_438_17"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203325"},{"key":"e_1_2_10_23_1","first-page":"92","article-title":"Presence of Epstein\u2010Barr virus in oral lichen planus and normal oral mucosa","volume":"36","author":"Sahebjamee M","year":"2007","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_10_24_1","first-page":"e560","article-title":"Epstein\u2010Barr virus is not detected in mucosal lichen planus","volume":"23","author":"Danielsson K","year":"2018","journal-title":"Medicina oral, patologia oral y cirugia bucal"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.174643"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03260023"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518788282"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00695"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2015.0020"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.09.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.92"}],"container-title":["Journal of Oral Pathology &amp; 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