{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:22Z","timestamp":1787015602711,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Increasing evidence suggests that aberrant expression of microRNAs (miRNAs) is involved in the pathogenesis of primary Sj\u00f6gren's syndrome (pSS). The aim was thus to characterize the miRNA profile in saliva, salivary gland tissue, and plasma from patients with pSS and compare findings with those of patients having Sj\u00f6gren\u2010like disease (non\u2010pSS). In addition, to correlate miRNA levels and clinicopathological features of pSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>miRNA real\u2010time quantitative polymerase chain reaction was performed on saliva, plasma, and salivary gland tissue samples from 24 patients with pSS and 16 non\u2010pSS in 384\u2010well plates. T test was used for comparison of miRNA profiles, followed by Benjamini\u2010Hochberg correction. The discriminatory power of miRNAs was evaluated by receiver\u2010operating characteristic curves, and Pearson\/Spearman correlation was used for correlation analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In saliva, 14 miRNAs were significantly differentially expressed between pSS and non\u2010pSS, including downregulation of the miR\u201017 family in pSS. In salivary gland tissue of patients with pSS, miR\u201029a\u20103p was significantly upregulated. Plasma miRNAs did not differ between the two groups, although the miR\u201017 family tended to be downregulated. The combination of miR\u201017\u20105p and let\u20107i\u20105p in saliva yielded an area under curve of 97% (CI 92%\u2010100%). Several miRNAs correlated significantly with one another and with salivary flow rates and histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that the miRNA expression profile in saliva may enable to discriminate between pSS and non\u2010pSS patients. However, further validation in larger cohorts is needed as well as functional analyses of the miRNAs of interest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13099","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T05:24:10Z","timestamp":1597555450000},"page":"1044-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Distinct microRNA expression profiles in saliva and salivary gland tissue differentiate patients with primary Sj\u00f6gren's syndrome from non\u2010Sj\u00f6gren's sicca patients"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-4740","authenticated-orcid":false,"given":"Maria Lynn","family":"Sembler\u2010M\u00f8ller","sequence":"first","affiliation":[{"name":"Section for Oral Biology and Immunopathology Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Belstr\u00f8m","sequence":"additional","affiliation":[{"name":"Section for Clinical Oral Microbiology Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Locht","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Frederiksberg Hospital Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie Lynge","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Section for Oral Biology and Immunopathology Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 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