{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:16Z","timestamp":1772160736774,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a chronic T cell\u2013mediated, immunological, mucocutaneous disease with a number of genes and inflammatory mediators implicated in its pathogenesis. Heart shock protein 70 and the proinflammatory mediator TNF\u03b1 have been predominantly involved in the etiopathogenesis of oral lichen planus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, the action of 27 commonly used drugs for treating OLP at HSP70 and TNF\u03b1 were evaluated by molecular docking using Maestro Schrodinger version 10.1. X\u2010ray crystallographic structures of the target proteins, that is, Heat Shock Protein 70 (PDB Code: 6FDT) and tumor necrosis factor alpha\u20101 (PDB Code: 1TNF) were obtained from Protein Data Bank (PDB). The structures of the ligands (27 drugs) were obtained from PubChem in.sdf format. Using Ligprep, pre\u2010processing of the ligands was done. Extra\u2010precision docking was performed with the prepared protein and the ligands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With respect to HSP70, the highest dock score (\u22124.768) and glide score (\u22124.818) were seen with hydroxychloroquine (HCQ), followed by epigallocatechin gallate (green tea), methotrexate, and curcumin. The highest dock (\u22129.525) and glide score (\u22129.584) in TNF\u03b1 were seen in with epigallocatechin gallate, followed by HCQ, dapsone, and methotrexate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of the study tend to explain the clinical use of HCQ in recalcitrant and severe cases, as well as the anti\u2010inflammatory property of epigallocatechin gallate. The results of the study open ventures for exploring the in silico behavior of drugs for effective pathological management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13100","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T06:52:58Z","timestamp":1598597578000},"page":"926-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["In silico evaluation of drugs used in treatment of oral lichen planus"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-3138","authenticated-orcid":false,"given":"Priyadharshini","family":"Ramakrishnan","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology Faculty of Dental Sciences Ramaiah University of Applied Sciences Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Pavan 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