{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:17:44Z","timestamp":1782908264322,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Histopathologic grading has been routinely used as a complement for clinical staging in the prognostication of patients with oral tongue squamous cell carcinoma (OTSCC). However, this subject remains contentious because there is no universally accepted grading system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study compared the prognostic significance of four histopathologic grading systems in 80 cases of oral tongue squamous cell carcinoma (OTSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and follow\u2010up information of the patients were obtained from medical records. Histopathologic malignancy grading of the tumor invasive front, Histologic risk assessment (HRA), World Health Organization (WHO) grading system, and Budding and Depth of invasion (BD) model were evaluated in the surgical specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HRA, histopathologic malignancy grading and WHO systems did not predict survival. Patients with larger tumor size [Hazard ratio (HR): 2.38; 95% confidence interval (CI): 1.07\u20105.27;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026] and patients with BD model high\u2010grade tumors (HR: 2.99; 95% CI: 1.03\u20108.68;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.034) were significantly associated with a poor 5\u2010year overall survival rate. In the multivariate analysis, tumor size was identified as the only significant independent prognostic factor (HR: 2.23; 95% CI: 1.00\u20104.99;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.050). None of the grading systems studied was associated with 5\u2010year disease\u2010free survival rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BD model was the only histopathologic grading system associated with the outcome of patients with OTSCC, indicating its potential value as an effective tool for the prognostication of OTSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13118","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T11:28:02Z","timestamp":1604575682000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Histopathologic grading and its relationship with outcome in oral tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-6581","authenticated-orcid":false,"given":"Luiz Arthur Barbosa da","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-1366","authenticated-orcid":false,"given":"Maria Luiza Diniz de Sousa","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melka Coelho","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Sergipe Aracaju Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-5375","authenticated-orcid":false,"given":"Roseana","family":"de Almeida Freitas","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-3046","authenticated-orcid":false,"given":"Ricardo Della","family":"Coletta","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis School of Dentistry University of Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-0147","authenticated-orcid":false,"given":"Ericka Janine Dantas","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-2566","authenticated-orcid":false,"given":"M\u00e1rcia Cristina","family":"da Costa Miguel","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205454"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24898"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.11.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.10.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12343"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.02.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1998.tb00260.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149687.90710.21"},{"key":"e_1_2_10_10_1","volume-title":"WHO Classification of Head and Neck Tumors","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23380"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.10.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0814-1"},{"key":"e_1_2_10_14_1","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours","author":"Barnes L","year":"2005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.01.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195451"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896907304992"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01068.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12990"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13481"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.01.014"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.01.027"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0749-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12643"},{"key":"e_1_2_10_28_1","first-page":"611","article-title":"Tumor budding, EMT and cancer stem cells in T1\u20132\/N0 oral squamous cell carcinomas","volume":"35","author":"Attramadal CG","year":"2015","journal-title":"Anticancer Res"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1758-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9070076"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.10.010"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.13118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T14:12:21Z","timestamp":1693663941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/jop.13118"],"URL":"https:\/\/doi.org\/10.1111\/jop.13118","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOP.13118\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13118\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13118\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13118\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13118\/v2\/response1","asserted-by":"object"}]},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"2020-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}