{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:51:13Z","timestamp":1792788673073,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salivary gland tumors are a diverse group of uncommon neoplasms that are rare in pediatric patients. The aim of this study was to evaluate the clinicopathological profile and survival outcomes of pediatric patients affected by salivary gland tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>An extensive search was carried out using the MEDLINE\/PubMed, EMBASE, Scopus databases, and grey literature. The risk of bias was available in all papers included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2,830 articles were initially retrieved with 54 remaining for data extraction, resulting in 2,937 cases. This comprised forty\u2010five case series\u2019 and nine cohort studies. These tumors were slightly more prevalent in females (57.4%). The patients' age ranged from 0.3 to 19\u00a0years old, with a mean age of 13.3\u00a0years. Parotid was the most affected site (81.9%), and 99.2% of cases clinically exhibited a swelling. Presence of pain\/tenderness was reported in 13.5% of the cases, with an average duration of 12.6\u00a0months for the appearance of symptoms. Most of the reported cases were malignant tumors (75.4%), with mucoepidermoid carcinoma the most common tumor of all tumors (44.8%), followed by pleomorphic adenoma (24.1%). Surgery alone was the leading treatment choice in 74.9% cases, and the 5\u2010year overall survival rate of patients was 93.1%. Patients with symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001), local recurrence (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), metastasis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and those not undergoing surgery or surgery combined with radiotherapy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) showed lower survival rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The pediatric patients present a high frequency of malignant salivary neoplasms and a high overall survival rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13151","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T11:47:09Z","timestamp":1607773629000},"page":"435-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-4008","authenticated-orcid":false,"given":"Brendo Vin\u00edcius Rodrigues","family":"Louredo","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-4911","authenticated-orcid":false,"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio","family":"Ajudarte Lopes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"},{"name":"Department of Oral Pathology School of Dentistry Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-1550","authenticated-orcid":false,"given":"Eliete Neves da Silva","family":"Guerra","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology Health Sciences Faculty University of Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Prado Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"},{"name":"Dental Oncology Service S\u00e3o Paulo State Cancer Institute School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Bianca","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Dental Oncology Service S\u00e3o Paulo State Cancer Institute School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Maria Holanda","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Boldrini Children\u2019s Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School State University of Campinas Piracicaba Brazil"},{"name":"Department of Head and Neck Surgery and Otorhinolaryngology AC Camargo Cancer Center S\u00e3o Paulo Brazil"},{"name":"Department of Head and Neck Surgery School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Speight","sequence":"additional","affiliation":[{"name":"Unit of Oral &amp; 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