{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:14Z","timestamp":1772160734634,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human Papillomavirus (HPV) role in oral potentially malignant lesions remains unclear. Aims of this study were to evaluate the prevalence of HPV infection in a cohort of patients affected by oral lichen planus, to analyze the genotypes involved, and to compare the performance of two specimen collection methods: brushing and biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Consecutive patients with oral lichen planus were enrolled. Each patient's clinical and anamnestic data were recorded before he\/she underwent brushing and biopsy procedures. The collected samples were analyzed using RT\u2010PCR. Prevalence of HPV infection was evaluated considering cytobrush and biopsy outcomes alone and combined. Correlation between HPV presence and sex, age, smoke, alcohol, kind of lichen planus, Hepatitis C virus, and involved mucosae was analyzed using chi\u2010square test (significance at\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Cohen's k coefficient was employed to compare brushing and biopsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010two patients affected by oral lichen planus were enrolled. Total HPV prevalence was 17%, when considering only the biopsy and the cytobrush the prevalence was 15% and 6%, respectively. None of the considered variables showed significant correlation with HPV (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). The concordance between the two methods was \u201cfair\u201d (k\u00a0=\u00a0.305).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The biopsy appears more reliable than cytobrush to detect HPV in course of oral lichen planus. No statistical correlation emerged with the analyzed variables. The most frequently detected genotypes were HPV 6 and 11, while only two cases presented with HPV 16 and 53, known as human oncogenic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13164","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T07:44:02Z","timestamp":1611733442000},"page":"716-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of HPV in patients affected by oral Lichen planus: A prospective study using two different chair\u2010side sampling methods"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-2039","authenticated-orcid":false,"given":"Fedora","family":"della Vella","sequence":"first","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-1812","authenticated-orcid":false,"given":"Dorina","family":"Lauritano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Centre of Neuroscience Milan University of Milan\u2010Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pannone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-3388","authenticated-orcid":false,"given":"Raffaele","family":"Del Prete","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-776X","authenticated-orcid":false,"given":"Dario","family":"Di Stasio","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Odontostomatological Specialties University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-6694","authenticated-orcid":false,"given":"Maria","family":"Contaldo","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Odontostomatological Specialties University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-3739","authenticated-orcid":false,"given":"Massimo","family":"Petruzzi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.077"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Oral lichen planus has a very low malignant transformation rate: a systematic review and meta\u2010analysis using strict diagnostic and inclusion criteria","author":"Idrees M","year":"2020","journal-title":"J Oral Pathol Med"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2015.04.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104550"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200401700113"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235861"},{"key":"e_1_2_10_8_1","unstructured":"https:\/\/www.cdc.gov\/cancer\/hpv\/statistics\/. 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