{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:00:40Z","timestamp":1782493240173,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872187"],"award-info":[{"award-number":["81872187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salivary gland extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue lymphoma (MALT lymphoma) is uncommon and has not been studied extensively. We aimed to investigate the features of clinicopathological and molecular changes of salivary MALT lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010two cases of primary salivary MALT lymphoma that had clinicopathological information available were utilized in this study. MALT1 gene translocation, trisomy 3, and trisomy 18 were detected by interphase fluorescence in situ hybridization (FISH). The data were analyzed using SPSS 17.0 software package.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ratio of male to female was 1:2.8, and the median age was 57.0\u00a0years. 12.5% (9\/72) of the patients presented with multiple swellings. Among the others with solitary mass, the parotid gland was involved most frequently (47\/63,74.6%), followed by the palate (7\/63, 11.1%). 34.7% of patients had an autoimmune disease, with Sj\u00f6gren syndrome (SS) being the most common. Among the 70 cases successfully performed, it was identified that trisomy 3 was the most frequent molecular change (41\/70, 58.6%), followed by trisomy 18 (7\/70, 10%) and MALT1 translocation (5\/70, 7.1%). The tumor tissue tended to exhibit trisomy 3 in patients without SS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038). The 5\u2010year overall survival was 94.1%, and the 5\u2010year disease\u2010free survival was 85.3% (mean follow\u2010up time: 104.7\u00a0months). The patients without SS and trisomy 18 had a prolonged recurrence\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001 respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Salivary gland MALT lymphoma is associated with autoimmune diseases, and trisomy 3 is the most common genetic change. Trisomy 18 can be used to predict the possibility of tumor relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13168","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T15:47:37Z","timestamp":1615996057000},"page":"723-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathological aspects of primary mucosa\u2010associated lymphoid tissue lymphoma of the salivary gland: A retrospective single\u2010center analysis of 72 cases"],"prefix":"10.1111","volume":"50","author":[{"given":"Chunye","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Department of Oral Pathology College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Disease Shanghai Ninth People\u2019s Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Xia","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology &amp; 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Shanghai Research Institute of Stomatology Department of Oral Pathology College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Disease Shanghai Ninth People\u2019s Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Ninth People\u2019s Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology College of Stomatology Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Department of Oral Pathology College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Disease Shanghai Ninth People\u2019s Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology &amp; 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