{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T20:09:34Z","timestamp":1775160574543,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004886","name":"Cancer Research Foundation in Northern Sweden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00209805"],"award-info":[{"award-number":["00209805"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["20 0754 PjF 01H"],"award-info":[{"award-number":["20 0754 PjF 01H"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Circulating markers are attractive molecules for prognosis and management of cancer that allow sequential monitoring of patients during and after treatment. Based on previous protein profiling data, circulating interleukin 1 receptor antagonist (IL\u20101Ra) was evaluated as a potential diagnostic and prognostic marker for squamous cell carcinomas of the head and neck (SCCHN). In this study, we aimed at confirming the clinical relevance of plasma IL\u20101Ra in SCCHN and exploring its potential as a prediction marker for SCCHN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma from 87 patients with SCCHN, control plasma from 28 healthy individuals and pre\u2010diagnostic plasma from 44 patients with squamous cell carcinoma of the oral tongue (SCCOT) and 88 matched controls were analysed with IL\u20101Ra electrochemiluminescence immunoassays from mesoscale diagnostics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma IL\u20101Ra was found to be up\u2010regulated in patients with oral tongue, gingiva and base of tongue tumours compared to healthy individuals (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). IL\u20101Ra levels positively correlated with tumour size (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and body mass index (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.013). Comparing pre\u2010diagnostic plasma to the matched controls, similar IL1\u2010Ra levels were seen (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The anti\u2010inflammatory cytokine IL\u20101Ra could be a diagnostic marker for SCCHN, whereas its potential as a cancer prediction marker was not supported by our data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13187","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T17:14:45Z","timestamp":1619025285000},"page":"785-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low potential of circulating interleukin 1 receptor antagonist as a prediction marker for squamous cell carcinoma of the head and neck"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-592X","authenticated-orcid":false,"given":"Linda","family":"Boldrup","sequence":"first","affiliation":[{"name":"Department of Medical Biosciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-6306","authenticated-orcid":false,"given":"Philip","family":"Coates","sequence":"additional","affiliation":[{"name":"Regional Centre for Applied Molecular Oncology Masaryk Memorial Cancer Institute Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-3628","authenticated-orcid":false,"given":"Xiaolian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"F\u00e5hraeus","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Regional Centre for Applied Molecular Oncology Masaryk Memorial Cancer Institute Brno Czech Republic"},{"name":"Institute of Molecular Genetics University of Paris St. Louis Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Wilms","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Ume\u00e5 University Ume\u00e5 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