{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:08:24Z","timestamp":1790190504174,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnosis of oral and maxillofacial mature T\/NK\u2010cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T\/NK\u2010cell neoplasms affecting this anatomical region and provided an updated literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases diagnosed as mature T\/NK\u2010cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin\u2010stained slides, immunohistochemical reactions and in situ hybridization for Epstein\u2010Barr virus (EBV) detection. Patients\u2019 clinical data were collected from their pathology forms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK\/T\u2010cell lymphomas, nasal type; eight (36.4%) were peripheral T\u2010cell lymphomas, NOS; two (9.1%) were adult T\u2010cell leukaemia\/lymphomas, and one (4.5%) was an ALK\u2010positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7\u00a0years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK\/T\u2010cell lymphoma nasal type but was absent in the other subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among mature T\/NK\u2010cell lymphomas of the oral and maxillofacial region, extranodal NK\/T\u2010cell lymphoma, nasal type and peripheral T\u2010cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13205","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T01:41:16Z","timestamp":1622943676000},"page":"548-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mature T\/NK\u2010Cell lymphomas of the oral and maxillofacial region: A multi\u2010institutional collaborative study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-3950","authenticated-orcid":false,"given":"Jos\u00e9 Alcides Almeida","family":"de Arruda","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte 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Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denize D'Azambuja","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-6636","authenticated-orcid":false,"given":"Cristiane Bedran","family":"Milito","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-3102","authenticated-orcid":false,"given":"Fl\u00e1via Sirotheau 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