{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:18:05Z","timestamp":1791483485660,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymphomas in the oral and oropharyngeal regions are relatively uncommon, and their diagnosis is challenging and complex due to the myriad histopathological subtypes. Herein, we report a large series of oral and oropharyngeal lymphomas and compare our data with the currently available literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All cases diagnosed as lymphomas affecting the oral and oropharyngeal regions were retrospectively retrieved from seven Brazilian institutions. Clinicodemographic data and histopathological features were evaluated and described, while a comprehensive literature review was undertaken in order to compare our findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 304 cases of oral and oropharyngeal lymphomas were obtained, mostly affecting individuals aged 60\u201369\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a068) with a mean age at diagnosis of 54.2\u00a0\u00b1\u00a020.1\u00a0years. Males and females were equally affected. Mature B\u2010cell neoplasms (87.2%) were the most common group, followed by mature T\u2010 and NK\u2010cell neoplasms (11.2%) and precursor lymphoid neoplasms (1.6%). The most frequent subtypes in each group were diffuse large B\u2010cell lymphomas, not otherwise specified (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a099), extranodal NK\/T\u2010cell lymphomas, nasal type (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a012), and B\u2010lymphoblastic leukaemia\/lymphomas, not otherwise specified (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04). The most commonly involved sites were the palate (26.3%), mandible (13%), and maxilla (10.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Diffuse large B\u2010cell lymphoma, not otherwise specified, remains the most common subtype of lymphomas in the oral and oropharyngeal region. Older patients are the most affected, with no gender predilection and the palate and jaw are usually affected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13211","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:44Z","timestamp":1623024044000},"page":"603-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Oral and oropharyngeal lymphomas: A multi\u2010institutional collaborative study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-3950","authenticated-orcid":false,"given":"Jos\u00e9 Alcides Almeida","family":"de Arruda","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-1277","authenticated-orcid":false,"given":"Nicolau","family":"Conte Neto","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-7796","authenticated-orcid":false,"given":"Lucas Lacerda","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-6235","authenticated-orcid":false,"given":"Carla Isabelly","family":"Rodrigues\u2010Fernandes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-8071","authenticated-orcid":false,"given":"Lucas Guimar\u00e3es","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Child\u2019s and Adolescent\u2019s Oral Health School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-6640","authenticated-orcid":false,"given":"Ciro Dantas","family":"Soares","sequence":"additional","affiliation":[{"name":"Private Pathology Laboratory  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-004X","authenticated-orcid":false,"given":"Maria Goretti Freire","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Private Pathology Laboratory  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-337X","authenticated-orcid":false,"given":"Michelle","family":"Agostini","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-606X","authenticated-orcid":false,"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-5916","authenticated-orcid":false,"given":"M\u00e1rio Jos\u00e9","family":"Roma\u00f1ach","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology School of Dentistry Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5721-9968","authenticated-orcid":false,"given":"Virgilio Gonzales","family":"Zanella","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Hospital Santa Rita Santa Casa de Miseric\u00f3rdia de Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-0461","authenticated-orcid":false,"given":"Marinez Bizarro","family":"Barra","sequence":"additional","affiliation":[{"name":"Service of Pathology Hospital Santa Rita Santa Casa de Miseric\u00f3rdia  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Department of Oral Medicine Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-8794","authenticated-orcid":false,"given":"Giovanna Ribeiro","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Dentistry Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-869X","authenticated-orcid":false,"given":"Adriana","family":"Etges","sequence":"additional","affiliation":[{"name":"Diagnostic Centre for Oral Diseases School of Dentistry Universidade Federal de Pelotas  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-8804","authenticated-orcid":false,"given":"H\u00e9lder Ant\u00f4nio Rebelo","family":"Pontes","sequence":"additional","affiliation":[{"name":"Service of Oral Pathology Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto Universidade Federal do Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-3102","authenticated-orcid":false,"given":"Fl\u00e1via Sirotheau Correa","family":"Pontes","sequence":"additional","affiliation":[{"name":"Service of Oral Pathology Hospital Universit\u00e1rio Jo\u00e3o de Barros Barreto Universidade Federal do Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-4911","authenticated-orcid":false,"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2002-8003","authenticated-orcid":false,"given":"Oslei Paes","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0065","authenticated-orcid":false,"given":"Marcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School Universidade de Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-8878","authenticated-orcid":false,"given":"F\u00e1bio Ram\u00f4a","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-4547","authenticated-orcid":false,"given":"Felipe Paiva","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-4007","authenticated-orcid":false,"given":"Ricardo Alves","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.17795\/ijcp-4124"},{"key":"e_1_2_9_3_1","volume-title":"Estimativa 2020: Incid\u00eancia de c\u00e2ncer no Brasil","author":"Instituto Nacional do C\u00e2ncer (INCA)","year":"2019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31820f7d07"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05544-z"},{"key":"e_1_2_9_6_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02543-7"},{"key":"e_1_2_9_8_1","first-page":"e23","article-title":"Oral cancer: a multicenter study","volume":"23","author":"Dhanuthai K","year":"2018","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.30721"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.4.1633"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.02.019"},{"key":"e_1_2_9_14_1","first-page":"43","article-title":"Extranodal oral non\u2010Hodgkin's lymphomas. a retrospective study of 40 cases in Argentina","volume":"21","author":"Keszler A","year":"2008","journal-title":"Acta Odontol Latinoam"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.08.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400007789"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-010-9173-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.11.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.116155"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01988.x"},{"key":"e_1_2_9_21_1","first-page":"66","article-title":"Head and neck lymphomas\u2010a retrospective ten\u2010year observation","volume":"21","author":"Niemiec M","year":"2017","journal-title":"Contemp Oncol (Pozn)"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.01.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01027-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102892"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.01.018"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12753"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1761970"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.08.018"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2012.47.2.92"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148809"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12802"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.13211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:37:38Z","timestamp":1693330658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jop.13211"],"URL":"https:\/\/doi.org\/10.1111\/jop.13211","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOP.13211\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}