{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:02:09Z","timestamp":1780498929119,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602380"],"award-info":[{"award-number":["81602380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073265"],"award-info":[{"award-number":["82073265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tertiary lymphoid structures have been observed in several solid tumors and suggested to be a favorable prognostic factor. However, the prognostic value of tertiary lymphoid structures for early clinical stage (cT1\/2N0) oral tongue squamous cell carcinoma (OTSCC) remains unclear. In this study, we aimed to evaluate the prognostic value of tertiary lymphoid structures in cT1\/2N0\u00a0stage OTSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010seven patients with cT1\/2N0 stage OTSCC were enrolled in this study. Tertiary lymphoid structures were assessed in paraffin sections with H.E and immunohistochemistry staining. Overall and disease\u2010free survivals were evaluated by the Kaplan\u2010Meier method. Cox proportional hazards regression models were used to assess their prognostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tertiary lymphoid structures can be readily identified in cT1\/2N0 stage OTSCC, including early tertiary lymphoid structures, primary follicle\u2010like tertiary lymphoid structures, and secondary follicle\u2010like tertiary lymphoid structures. Its frequency in OTSCC was 76.3% in the cohort. The presence of tertiary lymphoid structures was associated with favorable overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0176) and disease\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0183) in early clinical stage OTSCC. Cox regression models showed that tertiary lymphoid structures can serve as an independent prognostic factor for overall survival (HR\u00a0=\u00a00.434, 95% CI\u00a0=\u00a00.212\u20130.886,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022) and disease\u2010free survival (HR\u00a0=\u00a00.459, 95% CI\u00a0=\u00a00.235\u20130.897,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023) in early clinical stage OTSCC. The group of low maturity of TLS combined with pN positive had the lowest overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0094) and disease\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tertiary lymphoid structures are frequently observed in OTSCC. It is associated with a favorable prognosis for patients with cT1\/2N0 stage OTSCC and may be used to predict immunotherapy sensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13215","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T05:06:17Z","timestamp":1623647177000},"page":"776-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic value of tertiary lymphoid structures in early clinical stage oral tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-5064","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Department of Oral Pathology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Department of Oral Pathology Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangzhou 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