{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:27:29Z","timestamp":1778902049836,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The important roles of lncRNAs have been reported in cancers, including tongue squamous cell carcinoma (TSCC). Here, we investigated the functional role and molecular mechanisms of lncRNA <jats:italic>FOXC2\u2010AS1<\/jats:italic> in TSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression level of <jats:italic>FOXC2\u2010AS1<\/jats:italic> in TSCC was determined by RT\u2010qPCR. Its biological role was evaluated through colony formation assay, flow cytometry, wound healing, transwell, and Western blot analyses. The interactions among gene were tested by mechanistic investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>FOXC2\u2010AS1<\/jats:italic> expression was high in TSCC tissues and cells. Functional assays in vitro showed that silencing <jats:italic>FOXC2\u2010AS1<\/jats:italic> restrained cell proliferation, cell cycle, migration, invasion, and EMT. In the mechanism, it was verified that H3K27 acetylation (H3K27ac) triggered an increase in <jats:italic>FOXC2\u2010AS1<\/jats:italic> expression. Furthermore, <jats:italic>FOXC2\u2010AS1<\/jats:italic> was identified as a cytoplasmic lncRNA and served as a ceRNA to upregulate <jats:italic>E2F3<\/jats:italic> expression via sponging <jats:italic>miR\u20106868\u20105p<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>H3K27ac\u2010induced <jats:italic>FOXC2\u2010AS1<\/jats:italic> exhibits carcinogenic property in TSCC by the <jats:italic>miR\u20106868\u20105p<\/jats:italic>\/<jats:italic>E2F3<\/jats:italic> axis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13232","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T17:20:04Z","timestamp":1628270404000},"page":"1018-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["H3K27ac\u2010induced <i>FOXC2\u2010AS1<\/i> accelerates tongue squamous cell carcinoma by upregulating <i>E2F3<\/i>"],"prefix":"10.1111","volume":"50","author":[{"given":"Cuiting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology The Third Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Third Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Third Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-9793","authenticated-orcid":false,"given":"Han","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Third Affiliated Hospital Sun Yat\u2010Sen 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