{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:32Z","timestamp":1747186652925,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laminin receptor is a non\u2010integrin cell\u2010surface receptor that binds laminin present on the basement membrane. It has been reported to be associated with infiltration and metastasis of various malignant tumors. However, no studies regarding tongue cancer have been reported. This study aimed to clarify the role of laminin receptor in squamous cell carcinoma of the tongue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed immunohistochemical staining of specimens from 66 patients with squamous cell carcinoma of the tongue and assessed laminin receptor expression and clinicopathological factors. As epithelial\u2010mesenchymal transition has been shown to be associated with infiltration and metastasis of malignant tumors, staining for E\u2010cadherin, vimentin, and N\u2010cadherin were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 20 patients with postoperative recurrence, 14 exhibited high laminin receptor expression (<jats:italic>p<\/jats:italic> = 0.0025). Kaplan\u2010Meier analysis revealed a significantly shorter time to postoperative recurrence for the high laminin receptor expression group than that for the low laminin receptor expression group (<jats:italic>p<\/jats:italic> = 0.0008). Based on multivariate analyses for postoperative recurrence, high laminin receptor expression was associated with poor prognosis (high expression vs. low expression; HR =3.19, 95% CI =0.92\u201311.08; <jats:italic>p<\/jats:italic> = 0.0682). There was a correlation between laminin receptor and N\u2010cadherin (<jats:italic>p<\/jats:italic> = 0.0089) but not between laminin receptor and E\u2010cadherin (<jats:italic>p<\/jats:italic> = 0.369) or vimentin (<jats:italic>p<\/jats:italic> = 0.4221).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that high laminin receptor expression is a useful prognostic factor for postoperative recurrence and may be a target for molecular therapy to treat squamous cell carcinoma of the tongue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13247","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T09:19:32Z","timestamp":1632820772000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression and significance of laminin receptor in squamous cell carcinoma of the tongue"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-742X","authenticated-orcid":false,"given":"Katsuhisa","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"},{"name":"Dental and Oral Medical Center Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2657-8604","authenticated-orcid":false,"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiichiro","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kurume University Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Sanada","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Kakuma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Center Kurume University  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingo","family":"Kusukawa","sequence":"additional","affiliation":[{"name":"Dental and Oral Medical Center Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.0963"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990115)85:2<432::AID-CNCR22>3.0.CO;2-J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<287::AID-PATH762>3.0.CO;2-W"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199608)179:4<376::AID-PATH591>3.0.CO;2-V"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000011895"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.6.837"},{"key":"e_1_2_10_8_1","first-page":"227","article-title":"67\u2010Kilodalton laminin receptor expression correlates with worse prognostic indicators in non\u2010small cell lung carcinomas","volume":"3","author":"Fontanini G","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000184505.05662.b9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194947"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2014.10"},{"key":"e_1_2_10_12_1","first-page":"18","volume-title":"TNMclassification of malignant tumours","author":"Brierley JD","year":"2017"},{"key":"e_1_2_10_13_1","first-page":"155","article-title":"Prognostic and predictive factors in breast cancer by immunohistochemical analysis","volume":"11","author":"Allred DC","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000198234"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12111"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00060-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12296"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12268"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.199"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.03.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00870"},{"key":"e_1_2_10_22_1","first-page":"1321","article-title":"Identification of a novel function for 67\u2010kDa laminin receptor: Increase in laminin degradation rate and release of motility fragments","volume":"62","author":"Ardini E","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1842"},{"key":"e_1_2_10_24_1","first-page":"4222","article-title":"Transforming growth factor \u03b21 treatment leads to an epithelial\u2010mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal\u2010regulated kinase 2 activation","volume":"61","author":"Ellenrieder V","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1974"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.359"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0237-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.398"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.16.1224"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04947-9"},{"key":"e_1_2_10_31_1","first-page":"787","article-title":"67\u2010kDa laminin receptor increases cGMP to induce cancer\u2010selective apoptosis","volume":"123","author":"Kumazoe M","year":"2013","journal-title":"J Clin Invest"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.13247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T09:32:23Z","timestamp":1693128743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/jop.13247"],"URL":"https:\/\/doi.org\/10.1111\/jop.13247","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"type":"print","value":"0904-2512"},{"type":"electronic","value":"1600-0714"}],"subject":[],"published":{"date-parts":[[2021,10,11]]},"assertion":[{"value":"2021-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}