{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:38Z","timestamp":1787015678972,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970949"],"award-info":[{"award-number":["81970949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771080"],"award-info":[{"award-number":["81771080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a T\u2010cell\u2010mediated chronic inflammatory disease with uncertain aetiology. Mucosal\u2010associated invariant T (MAIT) cells and \u03b3\u03b4T cells are unconventional, innate\u2010like T cells with immunoregulatory capacity. This study aimed to investigate the potential effects of MAIT and \u03b3\u03b4T cells on the pathogenesis of OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Circulating MAIT cells and \u03b3\u03b4T cells were identified using flow cytometry. Surface proteins including CD4, CD8, CD69, CD103, CD49d, programmed death\u20101 (PD\u20101) and its ligand PD\u2010L1 were assessed. Cytokines containing interleukin (IL)\u20104, IL\u201017, interferon (IFN)\u2010\u03b3, granzyme B and tumour necrosis factor (TNF)\u2010\u03b1 released by MAIT and \u03b3\u03b4T cells were measured following PMA and ionomycin stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Circulating MAIT and \u03b3\u03b4T cells were deficient in OLP. The percentage of CD4\n                      <jats:sup>+<\/jats:sup>\n                      , CD69\n                      <jats:sup>+<\/jats:sup>\n                      , CD103\n                      <jats:sup>+<\/jats:sup>\n                      and PD\u20101\n                      <jats:sup>+<\/jats:sup>\n                      MAIT cells was increased in OLP, while that of CD8\n                      <jats:sup>+<\/jats:sup>\n                      and CD49d\n                      <jats:sup>+<\/jats:sup>\n                      MAIT cells was decreased. The percentage of CD103\n                      <jats:sup>+<\/jats:sup>\n                      , PD\u20101\n                      <jats:sup>+<\/jats:sup>\n                      and PD\u2010L1\n                      <jats:sup>+<\/jats:sup>\n                      \u03b3\u03b4T cells was upregulated in OLP. Both the MAIT and \u03b3\u03b4T cells in OLP produced less IL\u20104 than controls. The granzyme B\u2010producing MAIT cells were increased, while \u03b3\u03b4T cells secreting granzyme B and TNF\u2010\u03b1 were reduced in OLP. IL\u201017 and IFN\u2010\u03b3 in OLP MAIT and \u03b3\u03b4T cells were not significantly different from that in controls. The frequency of OLP MAIT cells and the MAIT\/\u03b3\u03b4T rate were positively associated with the disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The deficient MAIT and \u03b3\u03b4T cells expressing functional proteins and releasing cytokines may play an immunoregulatory role in the pathogenesis of OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13250","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T21:41:41Z","timestamp":1634074901000},"page":"74-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Characterization and function of circulating mucosal\u2010associated invariant T cells and \u03b3\u03b4T cells in oral lichen 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