{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:12Z","timestamp":1772160732247,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salivary gland tumors with papillary architecture and intestinal\u2010like mucinous cytologic features are rare. Their clinicopathologic and genetic features are not fully understood, and whether they represent one separate entity remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six salivary adenocarcinomas with papillary architecture and intestinal\u2010like mucinous cytologic features were reported. Immunostaining was done for CK7, CK20, CDX2, SOX10, S100, MUC1, MUC2, and MUC5AC. Tumor DNA samples were extracted for Sanger sequencing. Previously reported morphology\u2010analogous cases were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six cases involved the palate (2), retromolar region (1), submandibular region (1), tongue (1), and mandible (1). Five cases were followed up, with one case of recurrence 1\u00a0year after surgery, one death from cerebral infarction 7\u00a0days after surgery, and three cases without signs of recurrence or metastasis over 5\u00a0years. All cases had abundant mucinous production and presented a typical immunophenotype common to salivary primaries, CK7 &amp; MUC1 positive, CK20 &amp; CDX2 negative. Sanger sequencing demonstrated recurrent\n                      <jats:italic>AKT1 E17K<\/jats:italic>\n                      mutations in four cases (4\/6, 66.7%). A review of reported salivary intestinal\u2010like tumors revealed 3 out of 13 cases presented with papillary morphology and CDX2 negative. Some salivary papillary neoplasms with mucinous cytologic features termed as intraductal papillary neoplasms or mucinous adenocarcinomas were also reported with\n                      <jats:italic>AKT1 E17K<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We describe 6 cases of salivary gland papillary adenocarcinoma with intestinal\u2010like mucinous cytologic features, which are different from conventional intestinal\u2010type adenocarcinoma, presenting a consistent immunophenotype of CK7 &amp; MUC1 positive, CK20 &amp; CDX2 negative and exhibiting recurrent\n                      <jats:italic>AKT1 E17K<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13271","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:30:03Z","timestamp":1641295803000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Salivary gland papillary adenocarcinoma with intestinal\u2010like features: Clinicopathologic, immunohistochemical, and genetic study of six cases"],"prefix":"10.1111","volume":"51","author":[{"given":"Xiaoxiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology National Center of Stomatology  Beijing 100081 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology National Center of Stomatology  Beijing 100081 PR 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