{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:16Z","timestamp":1772160736614,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771126"],"award-info":[{"award-number":["81771126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2019Y9031"],"award-info":[{"award-number":["2019Y9031"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accumulating evidence shows that pleomorphic adenoma (PA) exhibits a unique capsular invasion and with a crucial role in recurrence. This study was designed to explore RNA expression profiles in salivary gland PA in an attempt to further analyse genes associate with capsule invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the expression profiles of 4\u00a0salivary gland PA patients by RNA\u2010sequencing. The principal functions of the differentially expressed mRNAs (DEGs) were explored using GO and KEGG analysis. Then, RT\u2010qPCR and correlation analyses were performed to verify the candidate DEGs in 59 PA patients, and immunohistochemical examinations were conducted to validate candidate DEGs. Finally, the COMP\u2010related genes were screened using correlation and biological pathway enrichment analysis, and further validated by RT\u2010qPCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 974 DEGs were significantly upregulated, and 1464 were downregulated (fold change \u22652.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Based on GO and KEGG analyses, extracellular matrix organization and the PI3K\u2010Akt signalling pathway might play pivotal roles in the tumorigenesis of PA. 40 DEGs were screened and validated by RT\u2010qPCR, 11 upregulated and 5 downregulated DEGs were consistent with the sequencing results. Cartilage oligomeric matrix protein (COMP) was identified to have a significant correlation with the capsular invasion of PA and expression of COMP in patients with invasive capsular PA was significantly stronger than PA. Finally, further results could reveal that 5\u00a0highest scoring genes were screened as hub genes for COMP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggested that COMP may be a prognostic target for PA and might contribute to its capsular invasion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13277","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T20:25:02Z","timestamp":1643315102000},"page":"290-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression of cartilage oligomeric matrix protein (COMP) associates with capsular invasion in salivary gland pleomorphic adenoma"],"prefix":"10.1111","volume":"51","author":[{"given":"Xiu","family":"Yao","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Oral Diseases School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Guan","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Sanming First Hospital Fujian Medical University  Sanming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Lin","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou 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