{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:21:43Z","timestamp":1792718503329,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This scoping review was done to study the immunohistochemical biomarkers involved in the pathogenesis and malignant transformation of oral submucous fibrosis (OSF), in literature published from 2010 to 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The protocol was adapted from the Joanna Briggs Institute Reviewer's Manual (2017), and reported according to the PRISMA guidelines for Scoping Reviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010six studies included in this review reported 84 immunohistochemical (IHC) biomarkers in OSF: 10 epithelial markers, 28 connective tissue markers, 22 proliferative markers, and 24 other biomarkers that are transcription factors, cancer stem cell markers, cell signaling markers, proteins, and enzymes. The commonly reported IHC biomarkers were alpha\u2010smooth muscle actin (\u03b1\u2010SMA) and E\u2010cadherin (seven articles each) followed by vascular endothelial growth factor (VEGF) and CD34 (six articles each), p53, p63, and Ki67 (five articles each). \u03b1\u2010SMA, Ki67, CD105, and hTERT were significantly increased in oral squamous cell carcinoma arising in a background of OSF (OSCC\u2010OSF) compared with OSF and normal subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The identified surrogate IHC biomarkers reported in OSF in this scoping review require validation with long\u2010term prospective studies to facilitate early diagnosis, for use in risk assessment, and plan appropriate treatment for OSF in clinical practice.<\/jats:p>\n                    <jats:p>Open Science Framework ID: osf.io\/epwra<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13280","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T04:54:39Z","timestamp":1643691279000},"page":"594-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Immunohistochemical biomarkers in oral submucous fibrosis: A\u00a0scoping review"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-0234","authenticated-orcid":false,"given":"Loganathan","family":"Kavitha","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospital  Chennai India"},{"name":"The Tamil Nadu Dr. MGR Medical University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-4145","authenticated-orcid":false,"given":"Kannan","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospital  Chennai India"},{"name":"The Tamil Nadu Dr. MGR Medical University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasamy","family":"Shyam","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry Faculty of Dentistry \u2013 Meenakshi Academy of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffer Hussain Shazia","family":"Fathima","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospital  Chennai India"},{"name":"The Tamil Nadu Dr. MGR Medical University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadgave","family":"Umesh","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry ESIC Dental College  Kalaburagi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London WHO Collaborating Centre for Oral Cancer  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"49","article-title":"Oral white lesions with special reference to precancerous and tobacco\u2010related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18\u201021 1994. 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