{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:16Z","timestamp":1772160736665,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>NLRP3 (NOD\u2010, LRR\u2010 and pyrin domain\u2010containing protein 3)\u2010induced pyroptosis is involved in the development of a variety of autoimmune diseases, but its role in IgG4\u2010related sialadenitis (IgG4\u2010RS) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Salivary gland tissues from 19 patients with IgG4\u2010RS were designated the experimental group, and peritumoral tissues from 20 patients with benign salivary gland tumours were designated the control group. The cell morphology and fibrosis in the IgG4\u2010RS samples were observed by haematoxylin\u2010eosin (H&amp;E) and Masson trichrome (MT) staining. Immunohistochemical (IHC) staining was used to determine pyroptosis\u2010related proteins (NLRP3, ASC (apoptosis\u2010associated speck\u2010like protein containing a CARD), Caspase\u20101, GSDMD (gasdermin family members, including digestive dermatin D), interleukin 1\u03b2 (IL\u20101\u03b2), and interleukin 18 (IL\u201018)) expression levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Increased lymphoid follicle proliferation, germinal centre plasma cell infiltration, and irregular fibrosis were observed in the experimental group compared with the control group. The NLRP3, ASC, Caspase\u20101, GSDMD, IL\u20101\u03b2, and IL\u201018\u00a0levels were significantly higher in the experimental group than in the control group (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggested that pyroptosis\u2010related proteins might be involved in IgG4\u2010RS pathogenesis. However, the specific cellular pathway involved and whether multiple cell death pathways contribute to the occurrence of IgG4\u2010RS still need to be further studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13290","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T05:34:15Z","timestamp":1645853655000},"page":"388-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical analysis of pyroptosis\u2010related protein expression in IgG4\u2010related sialadenitis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-0206","authenticated-orcid":false,"given":"Jiao","family":"Pu","sequence":"first","affiliation":[{"name":"Oncological Department of Oral &amp; Maxillofacial Surgery the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Jia","sequence":"additional","affiliation":[{"name":"Oncological Department of Oral &amp; Maxillofacial Surgery the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Oncological Department of Oral &amp; Maxillofacial Surgery the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Hu","sequence":"additional","affiliation":[{"name":"Oncological Department of Oral &amp; Maxillofacial Surgery the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Oncological Department of Oral &amp; 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