{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:03:08Z","timestamp":1779310988853,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgG4\u2010related disease is a fibroinflammatory and immune\u2010mediated condition, which has extremely variable clinical manifestations. In this study, we aim to investigate the clinicopathological features of IgG4\u2010related disease involving the oral and maxillofacial region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases of IgG4\u2010related disease manifesting in the oral and maxillofacial region were retrieved from three Brazilian institutions. Clinical and serological data were obtained from the patients' medical charts, while microscopic and immunohistochemical findings were revised by oral pathologists. Diagnosis followed the American College of Rheumatology\/European League against Rheumatism criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven patients diagnosed with IgG4\u2010related disease were included in this study. Women were affected in all analysed cases, with a mean age of 55.4\u2009years. Two patients presented with the clinical involvement of more than one oral and maxillofacial anatomic site. Therefore, our sample comprised nine oral and maxillofacial anatomic sites affected by IgG4\u2010related disease. The submandibular gland was affected in four cases, the tongue and the parotid gland in two cases each, and the palate in one case. In a few cases, exploratory lower lip biopsy was used as a diagnostic approach. A moderate\u2010to\u2010severe lymphoid infiltrate containing plasma cells and lymphocytes, with an increased IgG4\/IgG ratio, was common. Treatment varied and steroids were the most frequently used (57.4%). Six patients remained alive, while one died from unknown causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although major salivary glands are commonly affected by IgG4\u2010related disease, the oral cavity can also be involved, and lower lip biopsy may be an auxiliary diagnostic tool.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13296","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T02:52:58Z","timestamp":1648522378000},"page":"493-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral and maxillofacial manifestations of IgG4\u2010related disease: A clinicopathological study"],"prefix":"10.1111","volume":"51","author":[{"given":"Glauce Guimar\u00e3es","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School, University of Campinas  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Sirotheau Corr\u00eaa","family":"Pontes","sequence":"additional","affiliation":[{"name":"Service of Surgery and Oral Pathology Jo\u00e3o de Barros Barreto University Hospital, Universidade Federal do Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-6640","authenticated-orcid":false,"given":"Ciro Dantas","family":"Soares","sequence":"additional","affiliation":[{"name":"Private Cytopathology Laboratory  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Goretti Freire","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Private Cytopathology Laboratory  Natal 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Augusto","family":"Tanure","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Lacerda","family":"de Souza","sequence":"additional","affiliation":[{"name":"Service of Surgery and Oral Pathology Jo\u00e3o de Barros Barreto University Hospital, Universidade Federal do Par\u00e1  Bel\u00e9m Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School, University of Campinas  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-6235","authenticated-orcid":false,"given":"Carla Isabelly","family":"Rodrigues\u2010Fernandes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School, University of Campinas  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oslei 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