{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:30:23Z","timestamp":1787668223013,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005300","name":"Sveriges Tandl\u00e4karf\u00f6rbund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n A major challenge in the management of patients with oral leukoplakia is the difficulty to identify patients at high risk of developing oral squamous cell carcinoma. Our knowledge about genomic alterations in oral leukoplakia, and in particular those that progress to oral squamous cell carcinoma, is scarce and there are no useful biomarkers that can predict the risk of malignant transformation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Using a novel, custom\u2010made tissue microarray including 28 high\u2010risk oral leukoplakias and the corresponding oral squamous cell carcinomas from 14 cases that progressed to cancer, we assayed copy number alterations involving the oral squamous cell carcinoma driver genes\n CDKN2A<\/jats:italic>\n ,\n CCND1<\/jats:italic>\n ,\n EGFR<\/jats:italic>\n , and\n MYC<\/jats:italic>\n by fluorescence in situ hybridization. The copy number alterationss were correlated with clinicopathological data from all patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Copy number alterations were identified in 14\/24 oral leukoplakias, analyzable for one or more of the oral squamous cell carcinoma driver genes.\n EGFR<\/jats:italic>\n was the most frequently altered gene in oral leukoplakias with amplification\/gain in 43.5% followed by loss of\n CDKN2A<\/jats:italic>\n (26.1%), gains of\n CCND1<\/jats:italic>\n (26.1%), and\n MYC<\/jats:italic>\n (8.3%). Losses of\n CDKN2A<\/jats:italic>\n were more common in oral leukoplakias progressing to oral squamous cell carcinoma compared to those that did not. Copy number alterations were more common in oral squamous cell carcinomas than in oral leukoplakias.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our findings demonstrate that copy number alterations involving the oral squamous cell carcinoma drivers\n CDKN2A<\/jats:italic>\n ,\n EGFR<\/jats:italic>\n , and\n CCND1<\/jats:italic>\n occur in oral leukoplakias and suggest a possible role for these genes in the development and\/or progression of subsets of oral leukoplakias.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.13303","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T06:37:23Z","timestamp":1651300643000},"page":"546-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Recurrent copy number alterations involving\n \n EGFR<\/i>\n <\/scp>\n ,\n \n CDKN2A<\/i>\n <\/scp>\n , and\n \n CCND1<\/i>\n <\/scp>\n in oral premalignant lesions"],"prefix":"10.1111","volume":"51","author":[{"given":"Fredrik","family":"J\u00e4wert","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Otorhinolaryngology Oral and Maxillofacial Surgery, NU Hospital Group Trollh\u00e4ttan Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-1392","authenticated-orcid":false,"given":"Andr\u00e9","family":"Fehr","sequence":"additional","affiliation":[{"name":"Sahlgrenska Center for Cancer Research, Department of Pathology University of Gothenburg, Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"\u00d6hman","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy University 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