{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:20:05Z","timestamp":1792113605035,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral erythroplakia has been classically considered as the potentially malignant disorder with the highest rate of malignant development into squamous cell carcinoma. This critical systematic review and meta\u2010analysis aim to estimate the malignant development rate of oral erythroplakia and identify the associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and LILACS, with keywords \u201cerythroplakia,\u201d \u201cerythroplasia,\u201d \u201cmalignant transformation,\u201d \u201cmalignant development,\u201d \u201cmalignization,\u201d \u201ccarcinogenesis,\u201d \u201coral cancer,\u201d \u201coral squamous cell carcinoma,\u201d \u201cmouth neoplasm,\u201d and \u201cprognosis.\u201d Meta\u2010analysis was conducted using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten observational studies with 441 patients met the inclusion criteria, whose mean malignant development rate was 12.7% and with a mean follow\u2010up period of patients of 6.66\u2009years. In the initial biopsy, 42.8% of oral erythroplakia were already squamous cell carcinoma. The buccal mucosa was the most frequent location of oral erythroplakia, but the floor of the mouth was the most common site of malignant development. All patients who underwent malignant development showed epithelial dysplasia on the initial diagnostic biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall malignant development rate of OE in the meta\u2010analysis was 19.9%. We could not associate any specific clinicopathological feature with the malignant development. The presence of epithelial dysplasia in the initial biopsy remains the worst prognostic factor. Further observational studies on OE are needed, with well\u2010established diagnostic criteria and good clinical follow\u2010up, in order to identify the true risk of malignant development of oral erythroplakia and the related risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13304","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T10:48:51Z","timestamp":1651315731000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Critical update, systematic review, and meta\u2010analysis of oral erythroplakia as an oral potentially malignant disorder"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-4703","authenticated-orcid":false,"given":"Alejandro I.","family":"Lorenzo\u2010Pouso","sequence":"first","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group) Faculty of Medicine and Dentistry, University of Santiago de Compostela  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-4122","authenticated-orcid":false,"given":"Irene","family":"Lafuente\u2010Ib\u00e1\u00f1ez de Mendoza","sequence":"additional","affiliation":[{"name":"Oral Medicine and Oral Pathology, Department of Stomatology II University of the Basque Country\/EHU  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-9868","authenticated-orcid":false,"given":"Mario","family":"P\u00e9rez\u2010Say\u00e1ns","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group) Faculty of Medicine and Dentistry, University of Santiago de Compostela  A Coru\u00f1a Spain"},{"name":"Health Research Institute of Santiago de Compostela (IDIS), ORALRES group Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-8922","authenticated-orcid":false,"given":"Alba","family":"P\u00e9rez\u2010Jard\u00f3n","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group) Faculty of Medicine and Dentistry, University of Santiago de Compostela  A Coru\u00f1a Spain"},{"name":"Health Research Institute of Santiago de Compostela (IDIS), ORALRES group Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-9908","authenticated-orcid":false,"given":"Cintia M","family":"Chamorro\u2010Petronacci","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group) Faculty of Medicine and Dentistry, University of Santiago de Compostela  A Coru\u00f1a Spain"},{"name":"Health Research Institute of Santiago de Compostela (IDIS), ORALRES group Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-1834","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Blanco\u2010Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group) Faculty of Medicine and Dentistry, University of Santiago de Compostela  A Coru\u00f1a Spain"},{"name":"Health Research Institute of Santiago de Compostela (IDIS), ORALRES group Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-0968","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Aguirre\u2010Ur\u00edzar","sequence":"additional","affiliation":[{"name":"Oral Medicine and Oral Pathology, Department of Stomatology II University of the Basque Country\/EHU  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"378","article-title":"Erythroplasie de gland","volume":"22","author":"Queyrat L","year":"1911","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1948.01520210094014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(64)90499-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/208519"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.03.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.12.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12208"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.12.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197312)32:6<1436::AID-CNCR2820320622>3.0.CO;2-C"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200603210-00010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<1021::AID-CNCR2820360327>3.0.CO;2-W"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<345::AID-IJC2>3.0.CO;2-N"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(96)00011-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5935\/1676-2444.20140008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13183"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.10.016"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.10.021"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01191.x"},{"issue":"8","key":"e_1_2_10_26_1","first-page":"e448","article-title":"A clinicopathologic study of oral leukoplakia and erythroplakia in a Thai population","volume":"38","author":"Lapthanasupkul P","year":"2007","journal-title":"Quintessence Int"},{"key":"e_1_2_10_27_1","first-page":"112","volume-title":"WHO Classification of Head and Neck Tumours","author":"Reibel J","year":"2017"},{"key":"e_1_2_10_28_1","first-page":"324","article-title":"Epitheliome B\u00e9nin syphilo\u00efde de la verge (epith\u00e9lioma papillaire)","volume":"4","author":"Fournier A","year":"1983","journal-title":"Bull Soc Fran\u00e7 de Dermat et Syph"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100040974"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(50)90081-8"},{"issue":"4","key":"e_1_2_10_31_1","first-page":"341","article-title":"Erythroplasia of Queyrat","volume":"35","author":"Blau S","year":"1955","journal-title":"Acta Dermatol Venerol"},{"key":"e_1_2_10_32_1","first-page":"460","article-title":"Erythroplakia of the mouth","volume":"22","author":"Shear HL","year":"1972","journal-title":"Int Dent J"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00582.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2011.01337.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(76)90099-2"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250306"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90215-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90068-X"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90166-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0189"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(87)80049-8"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12709"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13993"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23576"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13810"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13246"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.13304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T01:54:40Z","timestamp":1692755680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jop.13304"],"URL":"https:\/\/doi.org\/10.1111\/jop.13304","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"2022-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}