{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:28:55Z","timestamp":1783790935175,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Depending on impairment, treatment of vascular anomalies is decided on a case\u2010by\u2010case basis in pluridisciplinary consultations. Interventional treatments, especially surgery and sclerotherapy, are usually partially efficient and management of patients with vascular anomalies increasingly involves the use of medical drugs. The most common vascular tumor is infantile hemangioma where first\u2010line medical treatment, when necessary, is propranolol. Kasabach\u2013Merritt phenomenon is now largely treated with sirolimus whereas first\u2010line treatment of coagulation disorders associated with venous malformations is based on low\u2010molecular\u2010weight heparins or direct anticoagulants. Sirolimus is the standard treatment for painful inflammatory manifestations of low\u2010flow vascular malformations such capillary, venous, and lymphatic malformations that can occur singly or in combination but PIK3CA inhibitors, originally developed in oncology, have shown promising results in patients with PIK3CA\u2010related overgrowth spectrum. Currently, medical treatments are poorly developed for high\u2010flow malformations such as arteriovenous malformations. However, new research aimed at delineating the different arteriovenous malformations based on molecular findings has given new hope for future development of targeted therapies.<\/jats:p>","DOI":"10.1111\/jop.13324","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T22:03:07Z","timestamp":1654552987000},"page":"837-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Medical management of vascular anomalies of the head and neck"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-2607","authenticated-orcid":false,"given":"Christine","family":"L\u00e9aut\u00e9\u2010Labr\u00e8ze","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Dermatologie P\u00e9diatrique et Centre de R\u00e9f\u00e9rence des Maladies Rares de la Peau d'Origine G\u00e9n\u00e9tique H\u00f4pital Pellegrin\u2010Enfants, CHU de Bordeaux  Bordeaux Cedex 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