{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:12:56Z","timestamp":1783948376563,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["19K10081"],"award-info":[{"award-number":["19K10081"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K18213"],"award-info":[{"award-number":["17K18213"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Polymorphous adenocarcinoma is a common intraoral minor salivary gland carcinoma in Western countries but is extremely rare in Japan. The current study aimed to characterize the clinicopathological features and status of molecular alterations of polymorphous adenocarcinoma\u2010associated genes, such as\n                      <jats:italic>PRKD1\/2\/3<\/jats:italic>\n                      ,\n                      <jats:italic>ARID1A<\/jats:italic>\n                      , and\n                      <jats:italic>DDX3X<\/jats:italic>\n                      , in a large cohort of Japanese patients with polymorphous adenocarcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We examined the cases of 36 Japanese patients with salivary gland polymorphous adenocarcinoma and 26 cases involving histopathological mimics. To detect gene splits, fluorescence in\n                      <jats:italic>situ<\/jats:italic>\n                      hybridization was carried out for polymorphous adenocarcinoma\u2010associated genes. Additionally, we applied a SNaPshot multiplex assay to identify\n                      <jats:italic>PRKD1<\/jats:italic>\n                      hotspot mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study revealed the indolent clinical course of polymorphous adenocarcinoma with a high 10\u2010year overall survival rate (92.9%), accompanied by occasional local recurrences and cervical lymph node metastasis (23.3%). Twenty cases (55.6%) of polymorphous adenocarcinoma (but none of the mimics) exhibited alterations in at least one polymorphous adenocarcinoma\u2010associated gene. Rearrangement of polymorphous adenocarcinoma\u2010associated genes and\n                      <jats:italic>PRKD1<\/jats:italic>\n                      E710D were identified in 17 (47.2%) and 4 (11.1%) cases, respectively; one case showed coexisting\n                      <jats:italic>PRKD3<\/jats:italic>\n                      split and\n                      <jats:italic>PRKD1<\/jats:italic>\n                      E710D. In the multivariate analysis, high clinical stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.0005), the presence of prominent nucleoli (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.0003), and\n                      <jats:italic>ARID1A<\/jats:italic>\n                      split positivity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.004) were independent risk factors for disease\u2010free survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Japanese patients with polymorphous adenocarcinoma showed clinicopathological features similar to those reported in Western countries. This study disclosed that polymorphous adenocarcinoma\u2010associated genetic alterations were common and specific findings in polymorphous adenocarcinomas. The diagnostic role and possible prognostic significance of polymorphous adenocarcinoma\u2010associated genetic alterations in polymorphous adenocarcinomas were suggested.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13336","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T16:19:19Z","timestamp":1658852359000},"page":"710-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Salivary gland polymorphous adenocarcinoma: Clinicopathological features and gene alterations in 36 Japanese patients"],"prefix":"10.1111","volume":"51","author":[{"given":"Masahiro","family":"Fukumura","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, School of Dentistry Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department 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