{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:20:07Z","timestamp":1785446407375,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study is to analyze if the results of the Oral Health Impact Profile\u201014 questionnaire (OHIP\u201014) in patients with primary Sj\u00f6gren's syndrome (pSS) are correlated with salivary flow and level of xerostomia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational cross\u2010sectional study was conducted in 61 patients (60 women, one man, mean age 57.64 [13.52]) diagnosed of pSS according to the American\u2010European Criteria (2002). After recording demographic, medical and dental data (decayed\u2010missing\u2010filled teeth index [DMFT]), unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Subsequently, UWS flow was categorized into two groups (&lt;0.1\u00a0ml\/min and\u2009\u22650.1\u00a0ml\/min) and SWS into three groups (&lt;0.1\u00a0ml\/min, 0.1\u20130.7\u00a0ml\/min and\u2009&gt;0.7\u00a0ml\/min). Patients also filled out a visual analog scale (VAS) for xerostomia and OHIP\u201014 for self\u2010reported quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data showed positive and significant correlation between OHIP\u201014 and xerostomia, based on VAS results (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.52;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). Furthermore, there was a negative correlation between UWS and OHIP\u201014 scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.34;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006) and VAS for xerostomia (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.09). No significant correlation was found between SWS and OHIP\u201014 or VAS neither between DMFT and OHIP\u201014. When assessing the level of QoL by the UWS and SWS flow categories a significant association was found for UWS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) but not for SWS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.11). The OHIP\u201014 values were higher in the groups with lower salivary flow. The multiple linear regression to predict OHIP\u201014 only selected VAS for xerostomia as a statistically significant predictor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased level of xerostomia and reduced UWS flow decrease oral health\u2010related QoL in patients with pSS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13348","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T13:59:56Z","timestamp":1661263196000},"page":"810-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Usefulness of implementing the\n                    <scp>OHIP<\/scp>\n                    \u201014 questionnaire to assess the impact of xerostomia and hyposalivation on quality of life in patients with primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-3183","authenticated-orcid":false,"given":"Julia","family":"Serrano","sequence":"first","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0920","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"L\u00f3pez\u2010Pintor","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Fern\u00e1ndez\u2010Castro","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital Puerta de Hierro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital Severo Ochoa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Juan","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital Madrid Sanchinarro  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EPOX\u2010SSp Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"S3","article-title":"One year in review 2019: Sj\u00f6gren's syndrome","volume":"37","author":"Cafaro GC","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.13839"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2018.03.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23254"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1354523X.2003.00987.x4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.11.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399918"},{"key":"e_1_2_10_9_1","first-page":"3","article-title":"Development and evaluation of the oral health impact profile","volume":"11","author":"Slade GD","year":"1994","journal-title":"Community Dent Health"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041172"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12358"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0158"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"137","article-title":"Validation of oral health impact profile\u201014 and its association with hypossialia in a Sj\u00f6gren syndrome Portuguese population","volume":"43","author":"Amaral J","year":"2018","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2018.12.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102019\u2010216114"},{"key":"e_1_2_10_17_1","volume-title":"Oral Health Surveys Basic Methods","author":"Organization WHO","year":"2013"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"E44","article-title":"Validation the oral health impact profile (OHIP\u201014sp) for adults in Spain","volume":"14","author":"Montero\u2010Martin J","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.111551"},{"key":"e_1_2_10_20_1","unstructured":"HulleySB CummingsSR BrownerWS GradyD NewmanTB.Designing clinical research: an epidemiologic approach.4th ed.:Lippincott Williams & Wilkins;2013.79.https:\/\/sample-size.net\/correlation-sample-size\/"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100722.2011.00891.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1795391"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201059078\u20100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2008.01919.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2018.04.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13070"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13327"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.850766"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24736"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100528.2006.00285.x"},{"issue":"4","key":"e_1_2_10_31_1","first-page":"13","article-title":"Encuesta de Salud Oral en Espa\u00f1a 2020","volume":"25","author":"Bravo P\u00e9rez M","year":"2020","journal-title":"RCOE"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.13348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:10:32Z","timestamp":1692648632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/jop.13348"],"URL":"https:\/\/doi.org\/10.1111\/jop.13348","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOP.13348\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13348\/v1\/review3","asserted-by":"object"}]},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"assertion":[{"value":"2022-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}