{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:30:23Z","timestamp":1781530223912,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Secretory carcinoma (SC) is a well\u2010established salivary gland malignancy that has earned its popularity for its unique clinicopathological behavior. Although it is an indolent malignancy, few of them have been reported with high grade transformation making it mandatory to differentiate it from its prime histological mimicker, acinic cell carcinoma (AciCC). Recently, many studies have been directed toward validating the sensitivity and specificity of pan\u2010TRK IHC for confirming\n                      <jats:italic>ETV6::NTRK3<\/jats:italic>\n                      gene fusion in SCs involving salivary gland.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the present systematic review was to establish the diagnostic utility of pan\u2010TRK immunostaining in histological differentiation of SC from AciCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>An electronic search was carried out using MEDLINE by PubMed, Scopus, Google scholar, Trip, Cochrane library and EMBASE databases. Articles in which SC assessed with pan\u2010TRK immunohistochemical expressions were included for systematic review and their staining pattern (cytoplasmic, nuclear and\/or combined), sensitivity, specificity, positive as well as negative predictive were gathered. Risk of bias was analyzed for each study using QUADAS\u20102 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen eligible articles were included for the quantitative analysis, which revealed positive immunostaining of pan\u2010TRK by nearly all the\n                      <jats:italic>ETV6::NTRK3<\/jats:italic>\n                      fusion prevalent SCs alongside negative expression in almost all the cases of AciCC with 100% of sensitivity as well as specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The evidence from the included studies supports that pan\u2010TRK immunostaining could be used as a reliable preliminary screening tool for discerning SC from AciCC.<\/jats:p>\n                    <jats:p>PROSPERO No: CRD42022308913.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13373","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:29:40Z","timestamp":1665192580000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic accuracy of\n                    <scp>pan\u2010TRK<\/scp>\n                    immunohistochemistry in differentiating secretory carcinoma from acinic cell carcinoma of salivary gland\u2014A systematic review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-5785","authenticated-orcid":false,"given":"Pooja","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oral Pathology King George's Medical University  Lucknow 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