{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:20Z","timestamp":1772160740277,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The chemokines play a crucial role in the recruitment of lymphocytes in oral lichen planus, and the activated epithelial cells are the main producers of the chemokines. However, the signals provoking chemokine secretion still remain to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The global expression profile of chemokines in oral epithelial cell line induced by IFN\u03b3 was determined by microarray analysis. The gene and protein expression was validated in primary culture of oral epithelial cells, and the effects of IFN\u03b3 on regulating chemokine production were compared with that of TNF\u03b1 and IL2. Moreover, the capability of primary culture of oral epithelial cells to attract peripheral lymphocytes in response to IFN\u03b3 was investigated in oral lichen planus patients, and the cell phenotype of the recruited lymphocytes was analyzed using flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IFN\u03b3 triggered the expression of multiple chemokines in the oral epithelial cells. The expression pattern of the chemokines closely resembled that in the epithelial cell layer of oral lichen planus lesions. Compared with IL2 and TNF\u03b1, IFN\u03b3 demonstrated a distinct maximal effect on the chemokines secretion in primary culture of oral epithelial cells. The migration of peripheral lymphocytes toward the culture supernatant of IFN\u03b3\u2010treated primary culture of oral epithelial cells was significantly enhanced in the oral lichen planus group compared to that in the healthy control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IFN\u03b3 plays an important role in the chemokine secretion and epidermotropic migration of lymphocytes in oral lichen planus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13383","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T02:39:18Z","timestamp":1667961558000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The critical role of\n                    <scp>IFN\u03b3<\/scp>\n                    in the epidermotropic migration of lymphocytes in oral lichen planus"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-0246","authenticated-orcid":false,"given":"Yuhong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, School of Stomatology The Fourth Military Medical University (FMMU)  Xi'an China"},{"name":"Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases State Key Laboratory of Military Stomatology  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Stomatology The Fourth Military Medical University (FMMU)  Xi'an China"},{"name":"Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases State Key Laboratory of Military Stomatology  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Stomatology The Fourth Military Medical University (FMMU)  Xi'an China"},{"name":"Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases State Key Laboratory of Military Stomatology  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-155X","authenticated-orcid":false,"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases State Key Laboratory of Military Stomatology  Xi'an China"},{"name":"Department of Oral Histology and Pathology, School of Stomatology The Fourth Military Medical University (FMMU)  Xi'an 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