{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:37:26Z","timestamp":1792809446013,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003401","name":"FAPEAL","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The advances in molecular technologies have allowed a better understanding of the molecular basis of odontogenic cysts and tumours. <jats:italic>PTCH1<\/jats:italic> mutations have been reported in a high proportion of odontogenic keratocyst. <jats:italic>BRAF<\/jats:italic> p.V600E are recurrent in ameloblastoma and <jats:italic>KRAS<\/jats:italic> p.G12V\/R in adenomatoid odontogenic tumour, dysregulating the MAPK\/ERK pathway. Notably, <jats:italic>BRAF<\/jats:italic> p.V600E is also detected in ameloblastic carcinoma, but at a lower frequency than in its benign counterpart ameloblastoma. Recently, adenoid ameloblastoma has been shown to be <jats:italic>BRAF<\/jats:italic> wild\u2010type and to harbour <jats:italic>CTNNB1<\/jats:italic> (\u03b2\u2010catenin gene) mutations, further suggesting that it is not an ameloblastoma subtype. <jats:italic>CTNNB1<\/jats:italic> mutations also occur in other ghost\u2010cell\u2010containing tumours, including calcifying odontogenic cysts, dentinogenic ghost cell tumours and odontogenic carcinoma with dentinoid, but the link between <jats:italic>CTNNB1<\/jats:italic> mutations and ghost cell formation in these lesions remains unclear. Regarding mixed tumours, <jats:italic>BRAF<\/jats:italic> p.V600E has been reported in a subset of ameloblastic fibromas, ameloblastic\u2010fibrodentinomas and fibro\u2010odontomas, in addition to ameloblastic fibrosarcoma. Such mutation\u2010positivity in a subset of samples can be helpful in differentiating some of these lesions from odontoma, which is <jats:italic>BRAF<\/jats:italic>\u2010wild\u2010type. Recently, <jats:italic>FOS<\/jats:italic> rearrangements have been reported in cementoblastoma, supporting its relationship with osteoblastoma. Collectively, the identification of recurrent mutations in these aforementioned lesions has helped to clarify their molecular basis and to better understand the interrelationships between some tumours, but none of these genetic abnormalities is diagnostic. Since the functional effect of pathogenic mutations is context and tissue\u2010dependent, a clear role for the reported mutations in odontogenic cysts and tumours in their pathogenesis remains to be elucidated.<\/jats:p>","DOI":"10.1111\/jop.13401","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T14:08:17Z","timestamp":1673446097000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The molecular basis of odontogenic cysts and tumours"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-8572","authenticated-orcid":false,"given":"Isadora Pereira","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Pathology, Biological Science Institute (ICB) Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-4179","authenticated-orcid":false,"given":"Victor Coutinho","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Institute (ICB) Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-0336","authenticated-orcid":false,"given":"Let\u00edcia Martins","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Institute (ICB) Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-4995","authenticated-orcid":false,"given":"Carolina Cavali\u00e9ri","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Institute (ICB) Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO Classification of Tumours Editorial Board.Head and Neck Tumours [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; 2022 [cited 2022 Sep 21]. (WHO Classification of Tumours Series 5th ed.; vol. 9).https:\/\/tumourclassification.iarc.who.int\/chapters\/52"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2022.108412"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790061101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13135"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12671"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13305"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63528-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0534-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.07.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4317"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.740788"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12443"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0194-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.03.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.05.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.10.037"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.08.017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13243"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01125-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14479"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2020.08.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.12.038"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13108"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14053"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12914"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01347-z"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12598"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03107-4"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001695"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.07.021"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.13401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:06:15Z","timestamp":1692716775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,23]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jop.13401"],"URL":"https:\/\/doi.org\/10.1111\/jop.13401","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,23]]},"assertion":[{"value":"2022-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}