{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:05:48Z","timestamp":1788606348242,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Oral candidiasis occasionally occurs in patients with oral lichen planus (OLP) or lichenoid reaction (OLR). However, not all patients undergoing corticosteroid therapy develop\n Candida<\/jats:italic>\n superinfection. Thus, the identification of prognostic risk factors may help to identify patients at risk of\n Candida<\/jats:italic>\n superinfection.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective cohort study was conducted to review patients with OLP\/OLR who received steroid therapy at a single dental hospital between January 2016 and December 2021. The prevalence of\n Candida<\/jats:italic>\n superinfection and prognostic factors were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty\u2010two eligible patients with OLP\/OLR were retrospectively reviewed. The overall prevalence of\n Candida<\/jats:italic>\n superinfection during the study period was 35.37%; the median time\u2010to\u2010event between initiation of corticosteroid therapy and diagnosis of superinfection was 60\u2009days (interquartile range; 34\u2013296). The ulcerative type of OLP\/OLR, number of topical steroid applications, poor oral hygiene, and oral dryness were significantly associated with superinfection (\n p<\/jats:italic>\n \u2009<\u20090.05; Fisher's Exact test) and were identified as prognostic factors in univariable risk ratio regression. Multivariable risk ratio regression revealed the ulcerative type of OLP\/OLR and number of topical steroid applications were significant prognostic factors for\n Candida<\/jats:italic>\n superinfection in patients with OLP\/OLR.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Candida<\/jats:italic>\n superinfection occurs in approximately one\u2010third of patients with OLP\/OLR undergoing corticosteroid therapy. Patients with OLP\/OLR should be closely monitored in the first 2\u00a0months (60\u2009days; median time to infection) after steroid prescription. The ulcerative type of OLP\/OLR and a higher number of topical steroid applications per day may represent prognostic factors to identify patients at risk of\n Candida<\/jats:italic>\n superinfection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.13420","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T10:53:39Z","timestamp":1678704819000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of and prognostic factors for\n \n Candida<\/i>\n <\/scp>\n superinfection in oral lichen planus and lichenoid reactions: A retrospective cohort study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-0539","authenticated-orcid":false,"given":"Jirayu","family":"Saepoo","sequence":"first","affiliation":[{"name":"Section of Oral Medicine, Department of Oral Diagnostic Sciences, Faculty of Dentistry Prince of Songkla University, Hatyai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-9421","authenticated-orcid":false,"given":"Duangporn","family":"Kerdpon","sequence":"additional","affiliation":[{"name":"Section of Oral Medicine, Department of Oral Diagnostic Sciences, Faculty of Dentistry Prince of Songkla University, Hatyai Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-2750","authenticated-orcid":false,"given":"Kanokporn","family":"Pangsomboon","sequence":"additional","affiliation":[{"name":"Section of Oral Medicine, Department of Oral Diagnostic Sciences, Faculty of Dentistry Prince of Songkla University, Hatyai Songkhla 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