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However, function and molecular mechanism of\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA in oral squamous cell carcinoma still need to clarify further.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Long non\u2010coding RNA microarray assay, in situ hybridization staining, clinicopathological data analysis were performed to investigate expression pattern of\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA in oral squamous cell carcinoma tissue samples. Constructing ectopically expressed\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA in oral squamous cell carcinoma cells via plasmids or siRNAs, then changeable abilities of proliferation and motility of these cells were observed in vitro and in vivo. RNA\u2010protein pulldown, RNA immunoprecipitation, and bioinformatics analyses were performed to explore potential pathways involved in\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA\u2010based regulation of malignant progression in oral squamous cell carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA was identified upregulated in oral squamous cell carcinoma tissue and correlated with nodal metastasis and clinical severity of patients. Overexpressed\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA increased percentage of 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine\u2010positive cells, viability, migration, and invasion rates of oral squamous cell carcinoma cells, while silenced\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA could observe weakened effects in vitro. Xenograft tumor formed by\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA\u2010overexpressed cells had bigger volume, faster growth rates, higher weight, and more Ki67\n                      <jats:sup>+<\/jats:sup>\n                      cells. Pulmonary metastasis induced by\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA\u2010silenced cells had fewer colony nodes, Ki67\n                      <jats:sup>+<\/jats:sup>\n                      cells, and CD31\n                      <jats:sup>+<\/jats:sup>\n                      blood vessels. Furthermore,\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA was mainly localized in nucleus of oral squamous cell carcinoma cells and bound Ras\u2010associated binding 1A. Silencing Ras\u2010associated binding 1A could damage mobile ability and phosphorylation levels of nuclear factor\u2010\u03baB\u00a0in oral squamous cell carcinoma cells induced by overexpressing\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA. Opposite trend was also observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Acting as a promoter in oral squamous cell carcinoma metastasis,\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA promotes oral squamous cell carcinoma cells proliferation and motility by regulating the\n                      <jats:italic>BRAF<\/jats:italic>\n                      \u2010activated non\u2010protein coding RNA\/Ras\u2010associated binding 1A complex, which activates nuclear factor\u2010\u03baB\u00a0signaling pathway.\n                    <\/jats:p>\n                  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