{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:01:40Z","timestamp":1777453300432,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Angiogenesis plays a vital role at the molecular level in various inflammatory lesions, that lead to their chronicity. Oral lichen planus is an immune\u2010mediated chronic inflammatory disorder. The angiogenetic role and exact mechanisms in oral lichen planus are still unclear due to a dearth of studies. Its clinical significance with angiogenesis also requires further elucidation necessitating a thorough review of the studies that have been conducted so far. The present review was designed to identify the dependence of oral lichen planus progression on angiogenesis which could aid in devising metronomic treatments required to halt the progression of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A thorough search was made using MEDLINE by PubMed, Scopus, Google scholar, Cochrane library, and EMBASE databases. Original research articles, that immunohistochemically evaluated angiogenesis in oral lichen planus were included for review. Risk of bias was analysed for each study using Modified Newcastle\u2010Ottawa scale and Review Manager 5.4 was used to output its result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine published articles were included for data synthesis. The most commonly employed antibody was CD34, however, upregulated VEGF expression was the principal while ICAM\u20101, VCAM\u20101, and PECAM\u20101 were critical angiogenic factors to mediate angiogenesis in oral lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current evidence supports that angiogenesis, a fundamental pathogenetic mechanism of oral lichen planus, leads to its persistence and chronicity. However, studies with a larger sample size, standard evaluation criteria, different subtypes, and adequate follow\u2010up are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13472","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T02:39:49Z","timestamp":1691548789000},"page":"803-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An exotic pathogenetic mechanism of angiogenesis in oral lichen planus\u2014A systematic review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-176X","authenticated-orcid":false,"given":"R.","family":"Keerthika","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences Pandit Bhagwat Dayal Sharma University of Health Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-2622","authenticated-orcid":false,"given":"Mala","family":"Kamboj","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences Pandit Bhagwat Dayal Sharma University of Health Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil","family":"Girdhar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences Pandit Bhagwat Dayal Sharma University of Health Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Narwal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences Pandit Bhagwat Dayal Sharma University of Health Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences Pandit Bhagwat Dayal Sharma University of Health Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-682X","authenticated-orcid":false,"given":"Rahul","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Dr D Y Patil Dental College and Hospital, Dr D Y Patil Vidyapeeth  Pimpri Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Juneja","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathologist  Franklin Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.84474"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3797"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2015.04.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"issue":"80","key":"e_1_2_13_6_1","first-page":"105","article-title":"Oral lichen planus: a disease or a spectrum of tissue reactions? 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