{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:14:59Z","timestamp":1773476099734,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["443714\/2014\u20102"],"award-info":[{"award-number":["443714\/2014\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma is characterized by high rates of morbidity and mortality. Evidence obtained for different types of cancer shows that tumor initiation, progression, and therapeutic resistance are regulated by heat shock factor 1. This research aimed to analyze the effects of heat shock factor 1 on the biological behavior of oral squamous cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinicopathological and immunoexpression study of heat shock factor 1 in 70 cases of oral tongue SCC and functional assays by gene silencing of this factor in an oral tongue SCC cell line.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Heat shock factor 1 was overexpressed in oral tongue SCC specimens compared to normal oral mucosa (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and in the SCC15 line compared to immortalized keratinocytes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005). No significant associations were observed between overexpression of heat shock factor 1 and clinicopathological parameters or survival rates of the oral tongue SCC cases in the present sample. In vitro experiments showed that heat shock factor 1 silencing inhibited cell proliferation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005) and cell cycle progression, with the accumulation of cells in the G0\/G1 phase (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). In addition, heat shock factor 1 silencing reduced cell invasion capacity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and epithelial\u2010mesenchymal transition, characterized by a decrease in vimentin expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and an increase in E\u2010cadherin expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Heat shock factor 1 may exert several functions that help maintain cell stability under the stressful conditions of the tumor microenvironment. Thus, strategies targeting the regulation of this protein may in the future be a useful therapeutic tool to control the progression of oral squamous cell carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13491","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:59:35Z","timestamp":1696273175000},"page":"961-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Silencing of heat shock factor 1 (\n                    <scp>HSF1<\/scp>\n                    ) inhibits proliferation, invasion, and epithelial\u2010mesenchymal transition in oral squamous cell carcinoma"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-6581","authenticated-orcid":false,"given":"Luiz Arthur Barbosa","family":"da Silva","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Department of Dentistry Federal University of Rio Grande do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-3689","authenticated-orcid":false,"given":"Lucas Melo","family":"da Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Department of Dentistry Federal University of Rio Grande do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-6127","authenticated-orcid":false,"given":"Ana Camila Pereira","family":"Massetti","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-9716","authenticated-orcid":false,"given":"Laudenice","family":"de Lucena 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