{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:15Z","timestamp":1772160735584,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin\u2013eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE\/PubMed, Web of Science, EMBASE, and Scopus were searched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Case series<\/jats:italic>\n                      : The mean age was 46.8\u2009years (female\u2010to\u2010male ratio 2:1). Lesion's mean size was 11.0\u2009mm (\u00b19.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15\u2009days to 96\u2009months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2\u2010positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3\u2010positive cells predominate over the CD20\u2010positive.\n                      <jats:italic>Scoping review<\/jats:italic>\n                      : 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female\u2010to\u2010male ratio 2.2:1), black\u2010skinned (64.1%), with a mean age of 36.13 (\u00b1\u200917.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown\/black macules, particularly on the buccal mucosa. TRP2\u2010positive melanocytes and T\u2010lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13495","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T19:15:23Z","timestamp":1697656523000},"page":"1013-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-1360","authenticated-orcid":false,"given":"Thalita Soares","family":"Tavares","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Surgery, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte 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