{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:18:44Z","timestamp":1789823924027,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oral submucous fibrosis (OSMF) is a well\u2010known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high\u2010risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to \u201cantioxidant treatment,\u201d \u201cburning sensation,\u201d and \u201cmouth opening.\u201d The quality assessment of controlled clinical studies adhered to Cochrane guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13503","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T02:28:30Z","timestamp":1703816910000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antioxidant treatments in patients with oral submucous fibrosis: A systematic review"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-3449","authenticated-orcid":false,"given":"Mart\u00edn","family":"P\u00e9rez\u2010Leal","sequence":"first","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences Department of Dentistry  Valencia Espa\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Lanciano","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences Department of Dentistry  Valencia Espa\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-2479","authenticated-orcid":false,"given":"Nicla","family":"Flacco","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences Department of Dentistry  Valencia Espa\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3054-997X","authenticated-orcid":false,"given":"Cristina","family":"Estornut","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences Department of Dentistry  Valencia Espa\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carmen","family":"Carceller","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences Department of Dentistry  Valencia Espa\u00f1a Spain"},{"name":"Department of Pharmacy Pharmaceutical Technology and Parasitology, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. 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