{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:33:47Z","timestamp":1789612427652,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tertiary lymphoid structures (TLSs) are observed in cancer\u2010invasive sites of various organs, and show evidence of tumor\u2010specific B and\/or T cells, suggesting an active humoral antitumor response. The aim of this study was to evaluate the relationship between TLSs and prognosis in patients with tongue squamous cell carcinoma (TSCC) after preoperative S\u20101 chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 196 TSCC cases, 111 patients who received preoperative S\u20101 chemotherapy were compared to 85 patients who did not receive chemotherapy. We investigated the incidence of TLSs in both preoperative biopsy and resected specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TLSs were present in 24 (12%) biopsy specimens and 31 (16%) resected specimens. TLSs were associated with clinicopathologically advanced cases and positivity for lymphatic invasion. None of the cases with pStage 0 (i.e., noninvasive cancer) showed TLSs. In preoperative S\u20101 chemotherapy cases, TLSs were significantly more common in those treated with S\u20101 for more than 21\u2009days and in those with treatment effects 0, Ia, and Ib. TLSs may not be a favorable prognostic factor by themselves but maybe a prognostic factor when combined with preoperative S\u20101 treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of TLSs was suggested to be a factor indicating a favorable prognosis when considering the indication for preoperative S\u20101 chemotherapy. The synergistic effect of S\u20101 by activating antitumor immunity may be associated with a better prognosis in TSCC patients with TLSs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13509","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T06:44:56Z","timestamp":1704523496000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tertiary lymphoid structures in tongue cancer: Association with clinicopathological parameters, preoperative S\u20101 chemotherapy response, and prognosis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-3865","authenticated-orcid":false,"given":"Mai","family":"Seki","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"},{"name":"Department of Oral and Maxillofacial Surgery, and Plastic Surgery Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-766X","authenticated-orcid":false,"given":"Takaaki","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"},{"name":"Department of Oral and Maxillofacial Surgery, and Plastic Surgery Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, and Plastic Surgery Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, and Plastic Surgery Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsunari","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Gunma University Graduate School of Medicine  Maebashi Gunma 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