{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:15Z","timestamp":1772160735523,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The causes of vitamin B12 (B12) deficiency are varied and mainly related to gastric disorders. Glossitis is a common oral manifestation of B12 deficiency and is often first seen by dentists. This study aimed to investigate the correlation between B12 deficiency\u2010related glossitis (B12\u2010def glossitis) and gastric serum biomarkers [gastrin\u201017(G17), pepsinogen I (PGI), pepsinogen II (PGII), and anti\u2010\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) antibodies], and preliminarily discuss the etiology of B12\u2010def glossitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted in patients complaining of glossodynia, burning sensation, or severe recurrent oral ulcers, but patients with a history of gastrectomy were excluded. All subjects underwent a uniform oral examination and hematological tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 243 patients, 133 with B12\u2010def glossitis were in the case group, and 110 with other oral mucosal diseases (non\u2010glossitis) and normal B12 levels were in the control group. In the case group, 84.2% (112\/133) showed high G17 and low PGI levels (G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      ). Univariate logistic regression showed that G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      was a high\u2010risk factor for B12\u2010def glossitis (OR: 92.44; 95% CI: 35.91, 238.02). Subgroup analyses in the case group showed that the G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      group presented with lower B12 levels and a lower positive rate of anti\u2010\n                      <jats:italic>H. pylori<\/jats:italic>\n                      antibodies compared to the non\u2010G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Gastric serum biomarkers in patients with B12\u2010def glossitis generally showed G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      , suggesting possible atrophy of gastric corpus and fundus mucosa. The G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      and non\u2010G17\n                      <jats:sup>hi<\/jats:sup>\n                      PGI\n                      <jats:sup>low<\/jats:sup>\n                      groups may represent different etiologies of B12 deficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13511","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:28:35Z","timestamp":1706657315000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>B12<\/scp>\n                    deficiency\u2010related glossitis is highly associated with high gastrin\u201017 and low pepsinogen 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Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"384","article-title":"Vitamin B12 deficiency: recognition and management","volume":"96","author":"Langan RC","year":"2017","journal-title":"Am Fam 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