{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:16:00Z","timestamp":1790745360140,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcription factors are important in the epithelial\u2010mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype. Thus, the objective of this study was to analyze the expression and identify the localization of cellular markers related to the epithelial\u2010mesenchymal transition process in salivary gland tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>The expression and localization of E\u2010CADERIN, N\u2010CADERIN, SLUG, SNAIL, and TWIST were evaluated, using immunohistochemistry, in 48 salivary gland tumors, being 17 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 17 mucoepidermoid carcinomas (MEC). these proteins were compared to clinical and histopathologic parameters. normal gland tissues were included for immunohistochemical comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ACC and MEC cases showed higher expression of SNAIL compared to PA. MEC showed high expression of SLUG and TWIST. Low expression of N\u2010CADHERIN, SNAIL, and TWIST in ACC was frequent in T3 and T4. High expression of TWIST in MEC was more frequent at age\u2009\u2265\u200940\u2009years A positive correlation was only observed between N\u2010cadherin\/SNAIL in ACC, between SNAIL\/TWIST in MEC, and between SLUG\/TWIST in PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided insight into EMT\u2010related proteins (E\u2010cadherin, N\u2010cadherin, SNAIL, SLUG, and TWIST) and their contribution to the maintenance of morphogenesis and the development of the salivary gland tumors and showed a positive correlation among N\u2010CADHERIN\/SNAIL in ACC and SNAIL\/TWIST in MEC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13516","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T02:29:33Z","timestamp":1707877773000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>E\u2010CADERIN, N\u2010CADERIN, SLUG, SNAIL<\/scp>, and <scp>TWIST<\/scp> contribute to epithelial\u2010mesenchymal transition in salivary gland tumors"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-2907","authenticated-orcid":false,"given":"Dandara Andrade","family":"de Santana","sequence":"first","affiliation":[{"name":"Dentistry and Health Postgraduate Program, School of Dentistry Federal University of Bahia  Salvador Brazil"},{"name":"Laboratory of Oral and Maxillofacial Pathology, School of Dentistry Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana Ramos","family":"Braga","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program, School of Dentistry Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-2668","authenticated-orcid":false,"given":"Cl\u00e1udia Malheiros","family":"Camillo\u2010Coutinho","sequence":"additional","affiliation":[{"name":"International Research Center A.C. Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health, School of Dentistry State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-0483","authenticated-orcid":false,"given":"Patr\u00edcia Ramos","family":"Cury","sequence":"additional","affiliation":[{"name":"Department of Periodontology Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-4983","authenticated-orcid":false,"given":"Daniel Araki","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Institute of Health and Society Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iguaracyra Barreto","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine School of Medicine  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-6503","authenticated-orcid":false,"given":"Fl\u00e1via Cal\u00f3","family":"de Aquino Xavier","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program, School of Dentistry Federal University of Bahia  Salvador Brazil"},{"name":"Laboratory of Oral and Maxillofacial Pathology, School of Dentistry Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7225-5879","authenticated-orcid":false,"given":"Jean Nunes","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program, School of Dentistry Federal University of Bahia  Salvador Brazil"},{"name":"Laboratory of Oral and Maxillofacial Pathology, School of Dentistry Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01420-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092466"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2624-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-022-01801-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36183"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512218"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01052.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4841-4"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"15","article-title":"Twist expression in pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma of salivary glands","volume":"32","author":"Pardis S","year":"2016","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-018-1680-y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.jomfp_337_21"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101118"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.11.010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2018.09.005"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109320"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25846"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2016.05.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0619-3"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339213"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20211754"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.724200"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.01.081"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.10.015"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.47162\/RJME.61.3.15"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.06.015"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.006"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01164-08"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144210"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-022-00739-1"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T01:45:46Z","timestamp":1710726346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jop.13516"],"URL":"https:\/\/doi.org\/10.1111\/jop.13516","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}