{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:15Z","timestamp":1772160735647,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate and compare the expression levels of TNF\u2010\u03b1, omentin\u20101, and IL\u20106 in periodontitis patients before and after treatment with biological antimicrobial peptide (AMP) periodontal gel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>There involved 86 periodontitis patients admitted to our hospital from January 2020 to March 2021. They were equally and randomly distributed into the study group and the control group. The efficacy and adverse reactions were compared between the two groups after treatment, Additionally, the sulcus bleeding index (SBI), plaque index (PLI), gingival index (GI), periodontal probing depth (PD), and levels of TNF\u2010\u03b1, omentin\u20101, and IL\u20106 were measured before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After treatment, the total effective rate of the study group was significantly higher than that of the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while the scores of four indicators (SBI, PLI, GI, and PD) and the levels of TNF\u2010\u03b1, omentin\u20101, and IL\u20106 in the study group were evidently lower than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The study group had 1 case of mild irritant reaction, with an adverse reaction rate of 2.33% (1\/43). And the control group had 1 case of nausea and 1 case of allergy, with an adverse reaction rate of 4.65% (2\/43). The adverse reactions demonstrated no statistical difference between the two groups (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.345,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.557).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The levels of TNF\u2010\u03b1 and IL\u20106 were highly expressed before the auxiliary therapy of biological AMP periodontal gel for periodontitis, alongside low expression of omentin\u20101. Subsequently, the biological antibacterial polypeptide periodontal gel demonstrated efficacy in the treatment of periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13518","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T17:19:00Z","timestamp":1708881540000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression of\n                    <scp>TNF<\/scp>\n                    \u2010\u03b1, omentin\u20101, and\n                    <scp>IL<\/scp>\n                    \u20106 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel"],"prefix":"10.1111","volume":"53","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology Wuhan No. 1 Hospital (Wuhan Hospital of Traditional Chinese &amp; Western Medicine)  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Wuhan No. 1 Hospital (Wuhan Hospital of Traditional Chinese &amp; Western Medicine)  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-021-03373-2"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2020.vol34.0026","article-title":"Periodontal disease and its impact on general health in Latin America. 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