{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:17Z","timestamp":1772160737173,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myofibromas are rare benign neoplasms composed of myoid cells and myofibroblasts. This study aimed to systematically review case reports and a series of myofibromas (MF) and myofibromatosis (MFT) occurring in the oral and maxillofacial regions in order to describe their main clinicopathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. Electronic searches were conducted in 2023 in four databases: MEDLINE\/PubMed, Web of Science, Scopus, and EMBASE. A manual search and a search in the grey literature were also conducted. The lesions were classified as MF or MFT according to their original report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 169 cases were included in this systematic review. Men were slightly more affected, with a painless nodule. When occurring in soft tissue, MF usually developed in the gingiva (mean age:29.23\u2009\u00b1\u200921.93\u2009years) and when it was intra\u2010osseous, it occurred more frequently in the posterior mandible (mean age:14.33\u2009\u00b1\u200915.62\u2009years). MFT occurred mainly in the mandible and was predominantly described as well\u2010circumscribed masses of spindle cells organized in fascicles with a prominent vascular activity in a hemangiopericytoma\u2010like pattern. The lesions were mainly positive for smooth muscle actin and vimentin immunomarkers. Surgical excision was the treatment of choice in the majority of cases and recurrence was observed in only three cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MF and MFT affect more men, with an indolent clinical course. Intra\u2010osseous tumors and MFT seem to occur more frequently in younger individuals. These lesions seem to have a good prognosis and low recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13537","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:14:40Z","timestamp":1715040880000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological features of myofibromas and myofibromatosis affecting the oral and maxillofacial region: A systematic review"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-5194","authenticated-orcid":false,"given":"Felipe Martins","family":"Silveira","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology and Oral Medicine, School of Dentistry Universidad de la Rep\u00fablica (UDELAR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-3713","authenticated-orcid":false,"given":"Laura Borges","family":"Kirschnick","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Barcelos","family":"S\u00f3","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Oral Medicine, School of Dentistry Universidad de la Rep\u00fablica (UDELAR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-6718","authenticated-orcid":false,"given":"Vanesa","family":"Pereira Prado","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Oral Medicine, School of Dentistry Universidad de la Rep\u00fablica (UDELAR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefania","family":"Sicco","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Oral Medicine, School of Dentistry Universidad de la Rep\u00fablica (UDELAR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Rodrigues","family":"Lima","sequence":"additional","affiliation":[{"name":"Institute of Biological Science Federal University of Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell Eduardo","family":"Bologna\u2010Molina","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Oral Medicine, School of Dentistry Universidad de la Rep\u00fablica (UDELAR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto","family":"Mosqueda\u2010Taylor","sequence":"additional","affiliation":[{"name":"Health Care Department Universidad Aut\u00f3noma Metropolitana Xochimilco  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-9536","authenticated-orcid":false,"given":"Ana Carolina Uchoa","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Oral Diseases, Dental School Federal University of Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas  Piracicaba Brazil"},{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010020\u201001162\u2010y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000732"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(94)90241\u20100"},{"key":"e_1_2_7_5_1","first-page":"603","article-title":"Cutaneous myofibroma","volume":"2","author":"Smith KJ","year":"1989","journal-title":"Mod Pathol"},{"key":"e_1_2_7_6_1","first-page":"548","article-title":"Congenital fibrosarcoma; 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