{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:20Z","timestamp":1772160740343,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671006"],"award-info":[{"award-number":["81671006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901680"],"award-info":[{"award-number":["30901680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This Bayesian network meta\u2010analysis was performed to analyze the associations between clinicopathological characteristics and\n                      <jats:italic>BRAF<\/jats:italic>\n                      mutations in ameloblastoma (AM) patients and to evaluate the diagnostic accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Four electronic databases were searched from 2010 to 2024. The search terms used were specific to\n                      <jats:italic>BRAF<\/jats:italic>\n                      and AM. Observational studies or randomized controlled trials were considered eligible. The incidence of\n                      <jats:italic>BRAF<\/jats:italic>\n                      mutation and corresponding clinicopathological features in AM patients were subjected to Bayesian network analyses and diagnostic accuracy evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 937 AM patients from 20 studies were included. The pooled prevalence of\n                      <jats:italic>BRAF<\/jats:italic>\n                      mutations in AM patients was 72%. According to the Bayesian network analysis,\n                      <jats:italic>BRAF<\/jats:italic>\n                      mutations are more likely to occur in younger (odds ratio [OR], 2.3; credible interval [CrI]: 1.2\u20134.5), mandible site (OR, 3.6; 95% CrI: 2.7\u20135.2), and unicystic (OR, 1.6; 95% CrI: 1.1\u20132.4) AM patients. Similarly, higher diagnostic accuracy was found in the younger, mandible, and unicystic AM groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The incidence, risk, and diagnostic accuracy of\n                      <jats:italic>BRAF<\/jats:italic>\n                      mutation in AM were greater in younger patients, those with mandible involvement, and those with unicystic AM than in patients with other clinicopathological features. In addition, there was a strong concordance in the diagnostic accuracy between molecular tests and immunohistochemical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13542","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T20:58:42Z","timestamp":1716411522000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological characteristics and diagnostic accuracy of\n                    <i>BRAF<\/i>\n                    mutations in ameloblastoma: A Bayesian network analysis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-8601","authenticated-orcid":false,"given":"Ao\u2010Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of stomatology Shandong Public Health Clinical Center  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Ying","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-3739","authenticated-orcid":false,"given":"Li\u2010Sha","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-2985","authenticated-orcid":false,"given":"Tie\u2010Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences (2019RU034)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01435-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12646"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.12.016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-023-01993-z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.160"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210409"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011254"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.08.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.675523"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2023.08.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12474"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys222"},{"key":"e_1_2_10_16_1","unstructured":"Virchows Arch: Int J Pathol 439 Gsalpha gene mutations in monostotic fibrous dysplasia of bone and fibrous dysplasia\u2010like low\u2010grade central osteosarcoma"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4317"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13095"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2986"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1380"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-013-0142-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0799"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518798810"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3760"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v11.i1.31"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4802-y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13278"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01166-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12851"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13494"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13458"}],"container-title":["Journal of Oral Pathology &amp; 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