{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:51:43Z","timestamp":1784742703031,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Head and neck cancer encompasses neoplasms affecting the oral cavity, pharynx, larynx, and thyroid. Identifying factors that modulate the carcinogenesis process can aid in identifying subgroups at higher risk of developing the disease, enabling implementation of prevention programs. Vitamin D receptor polymorphisms can affect the carcinogenesis of various tumors by altering vitamin D metabolism and cellular response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To elucidate the role of vitamin D receptor polymorphisms in head and neck cancer, a systematic review was performed, searching the Embase, PubMed, Scopus, and Lilacs databases. A total of 19 articles met the inclusion criteria. The frequency of vitamin D receptors polymorphism alleles (FokI, ApaI, BsmI, TaqI, Cdx2, rs2107301, rs2238135) was recorded and pooled to calculate the odds ratio in a meta\u2010analysis using the Review Manager software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subgroup analysis demonstrated significant associations in the anatomical site of cancer (oral cancer in ApaI and BsmI, and unspecified subsites of head and neck cancer in TaqI), genotyping method (FokI and BsmI), and continent of the study (ApaI, FokI, and BsmI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings were heterogeneous, as with other evidence available in the literature. Therefore, more clinical studies with larger sample sizes are needed to obtain more accurate results on the relationship between vitamin D receptor polymorphism and head and neck cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13543","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T18:52:28Z","timestamp":1716490348000},"page":"341-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is vitamin D receptor (VDR) polymorphism associated with head and neck cancer risk? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Camila Alves","family":"Ferri","sequence":"first","affiliation":[{"name":"Oral Pathology and Oral Medicine Department, School of Dentistry Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Justo","family":"de Lima","sequence":"additional","affiliation":[{"name":"Oral Pathology and Oral Medicine Department, School of Dentistry Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Koehler","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Experimental Center Research Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis Varvaki","family":"Rados","sequence":"additional","affiliation":[{"name":"Oral Pathology and Oral Medicine Department, School of Dentistry Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4033-8431","authenticated-orcid":false,"given":"Fernanda","family":"Visioli","sequence":"additional","affiliation":[{"name":"Oral Pathology and Oral Medicine Department, School of Dentistry Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Experimental Center Research Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13502"},{"issue":"9","key":"e_1_2_10_3_1","first-page":"11884","article-title":"Essentials of oral cancer","volume":"8","author":"Rivera C","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02958-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9779-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04227.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485322"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01164.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.11.014"},{"issue":"8","key":"e_1_2_10_12_1","first-page":"3991","article-title":"Vitamin D receptor polymorphism and cancer: an update","volume":"37","author":"Rai V","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.201939"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0038-9"},{"issue":"9","key":"e_1_2_10_15_1","first-page":"3511","article-title":"The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature","volume":"29","author":"K\u00f6stner K","year":"2009","journal-title":"Anticancer Res"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-46227-7_4"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"755","article-title":"Association of vitamin D receptor Taq I polymorphism and susceptibility to bucal squamous cell carcinoma","volume":"24","author":"Bektas\u2010Kayhan K","year":"2010","journal-title":"In Vivo"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029634"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0388"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"317","article-title":"Evaluation of vitamin D receptor gene polymorphisms in patients with differentiated thyroid carcinomas and nodular goiter","volume":"46","author":"Gunes A","year":"2021","journal-title":"Minerva Endocrinol (Torino)"},{"key":"e_1_2_10_25_1","first-page":"299","article-title":"Vitamin D receptor gene polymorphisms in patients with thyroid cancer","volume":"11","author":"Haghpanah V","year":"2007","journal-title":"Gene Ther Mol Biol"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12977"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428318811766"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1299873"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-018-0164-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2008.04.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2012.00336"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0827-x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-011-9322-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_109_22"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2012_2102"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2011.v5.3.99"},{"issue":"23","key":"e_1_2_10_37_1","first-page":"1803","article-title":"Association of vitamin D receptor and its genetic polymorphisms with nasopharyngeal carcinoma","volume":"31","author":"Li W","year":"2017","journal-title":"J Clin Otorhinolaryngol Head Neck Surg (China)"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.110510"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200503000-00004"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.05.014"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41392"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i14.1672"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032575"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123819"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.9.2667"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-1632"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317731280"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194815"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T02:47:08Z","timestamp":1720147628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/jop.13543"],"URL":"https:\/\/doi.org\/10.1111\/jop.13543","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOP.13543\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.13543\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"2023-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}