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This SR was performed in accordance with the PRISMA 2022 guidelines and was registered in the PROSPERO database (CRD42022379298).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The acronym PICOS was used to structure the inquiry\u2010focused review question \u201cIs Artificial Intelligence reliable for the diagnosis of intraosseous lesions in gnathic bones?\u201d The literature search was conducted in various electronic databases, including PubMed, Embase, Scopus, Cochrane Library, Web of Science, Lilacs, IEEE Xplore, and Gray Literature (Google Scholar and ProQuest). Risk of bias assessment was performed using PROBAST, and the results were synthesized by considering the task and sampling strategy of the dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010six studies were included (21\u2009146 radiographic images). Ameloblastomas, odontogenic keratocysts, dentigerous cysts, and periapical cysts were the most frequently investigated lesions. According to TRIPOD, most studies were classified as type 2 (randomly divided). The F1 score was presented in only 13 studies, which provided the metrics for 20 trials, with a mean of 0.71 (\u00b10.25).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is no conclusive evidence to support the usefulness of ML\u2010based models in the detection, segmentation, and classification of intraosseous lesions in gnathic bones for routine clinical application. The lack of detail about data sampling, the lack of a comprehensive set of metrics for training and validation, and the absence of external testing limit experiments and hinder proper evaluation of model performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13548","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T02:06:01Z","timestamp":1716948361000},"page":"415-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Artificial intelligence and radiomics in the diagnosis of intraosseous lesions of the gnathic bones:\n                    <scp>A<\/scp>\n                    systematic review"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7150-3025","authenticated-orcid":false,"given":"Daniela","family":"Giraldo\u2010Rold\u00e1n","sequence":"first","affiliation":[{"name":"Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-8051","authenticated-orcid":false,"given":"Anna Lu\u00edza Damaceno","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department University of S\u00e3o Paulo Medical School (FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-6653","authenticated-orcid":false,"given":"Matheus Cardoso","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Institute of Science and Technology Federal University of S\u00e3o Paulo (ICT\u2010Unifesp)  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8688-7122","authenticated-orcid":false,"given":"Viviane Mariano","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Institute of Science and Technology Federal University of S\u00e3o Paulo (ICT\u2010Unifesp)  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1156-6539","authenticated-orcid":false,"given":"Erin Crespo Cordeiro","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Institute of Science and Technology Federal University of S\u00e3o Paulo (ICT\u2010Unifesp)  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3587-490X","authenticated-orcid":false,"given":"Matheus","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Institute of Mathematics and Computer Science (ICMC \u2013 USP) University of S\u00e3o Paulo  S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-2164","authenticated-orcid":false,"given":"Cristina","family":"Saldivia\u2010Siracusa","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-8723","authenticated-orcid":false,"given":"Sebasti\u00e3o Silv\u00e9rio","family":"Sousa\u2010Neto","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-2671","authenticated-orcid":false,"given":"Maria Eduarda","family":"P\u00e9rez\u2010de\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0065","authenticated-orcid":false,"given":"Marcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (FOP\u2010UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-156X","authenticated-orcid":false,"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department University of S\u00e3o Paulo Medical School (FMUSP)  S\u00e3o Paulo Brazil"},{"name":"Department of Head and Neck Surgery and Otorhinolaryngology A.C. 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