{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:20:39Z","timestamp":1776093639037,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Salivary gland tumors (SGTs) are a heterogenous group of pathologies, which still represents a challenge regarding differential diagnosis and therapy. Although histological findings govern SGTs management, detection of molecular alterations is emerging as an effective additional tool. The aim of this study was to analyze the relative expression levels of three micro RNAs (miR\u201026a, miR\u201026b, and miR\u2010191), and three pro\u2010oncogenic molecular markers (\n PLAG1<\/jats:italic>\n ,\n MTDH<\/jats:italic>\n , and\n HIF2<\/jats:italic>\n ) in SGTs and normal salivary gland (NSG) tissues and evaluate them as potential differential diagnosis markers.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This cross\u2010sectional study included 58 patients with SGTs (23 pleomorphic adenomas, 27 Warthin tumors, and 8 malignant SGTs) and 10 controls (normal salivary gland tissues). Relative gene expression levels of all investigated molecules were determined by reverse transcriptase\u2010real\u2010time polymerase chain reaction.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All three micro\n RNAs<\/jats:styled-content>\n exhibited highest expression levels in benign\n SGTs<\/jats:styled-content>\n , whereas\n miR<\/jats:styled-content>\n \u201026a And\n miR<\/jats:styled-content>\n \u2010191 were significantly more expressed in\n PAs<\/jats:styled-content>\n compared to\n WTs<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u2009=\u20090.045 and\n p<\/jats:italic>\n \u2009=\u20090.029, respectively).\n \n PLAG1<\/jats:italic>\n <\/jats:styled-content>\n And\n \n HIF2<\/jats:italic>\n <\/jats:styled-content>\n were both overexpressed in\n WTs<\/jats:styled-content>\n compared to\n PAs<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u2009=\u20090.048 and\n p<\/jats:italic>\n \u2009=\u20090.053, respectively). Bioinformatic analysis suggested that all investigated micro\n RNAs<\/jats:styled-content>\n function as negative regulators of\n \n MTDH<\/jats:italic>\n <\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results of this study suggest that all three micro RNAs have a considerable negative impact on\n MTDH<\/jats:italic>\n oncogene expression in malignant tumors, while the differences between levels of miR\u201026a, miR\u2010191,\n PLAG1<\/jats:italic>\n , and\n HIF2<\/jats:italic>\n in PA and WT represent possible differential diagnosis markers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.13565","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T02:43:32Z","timestamp":1717987412000},"page":"451-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MiR<\/scp>\n \u201026a and\n miR<\/scp>\n \u2010191 are upregulated while\n \n PLAG1<\/i>\n <\/scp>\n and\n \n HIF2<\/i>\n <\/scp>\n are downregulated in pleomorphic adenomas of the salivary glands compared to Warthin tumors"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-7589","authenticated-orcid":false,"given":"Jelena","family":"Carkic","sequence":"first","affiliation":[{"name":"School of Dental Medicine, Implant Research Center University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-9313","authenticated-orcid":false,"given":"Nadja","family":"Nikolic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Implant Research Center University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Sango","sequence":"additional","affiliation":[{"name":"Faculty of Biology University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-5236","authenticated-orcid":false,"given":"Nicole","family":"Riberti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boban","family":"Anicic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, Clinic for Maxillofacial Surgery University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-7210","authenticated-orcid":false,"given":"Jelena","family":"Milasin","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Dental Medicine University of Belgrade Belgrade 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