{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:24:52Z","timestamp":1789467892616,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500850"],"award-info":[{"award-number":["81500850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The specific mechanism underlying the role of oral lichen planus\u2010activated fibroblasts in angiogenesis remains undefined. Herein, the expression of Galectin\u20103 in oral lichen planus and verifying whether Galectin\u20103 can promote angiogenesis through oral lichen planus\u2010activated fibroblasts has been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The expression of Galectin\u20103 and CD34 in the oral lichen planus tissues (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) and normal oral mucosa tissues (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) was detected by immunohistochemistry. The expression of Galectin\u20103 in the oral lichen planus\u2010activated fibroblasts was determined by reverse transcription\u2010polymerase chain reaction, Western blot, and enzyme\u2010linked immunosorbent assay. Galectin\u20103 overexpression lentiviral vector was constructed and transfected with oral lichen planus\u2010activated fibroblasts. In addition, oral lichen planus\u2010activated fibroblasts were treated with GB1107 (5 and 10\u2009\u03bcM) to inhibit Galectin\u20103 expression and co\u2010cultured with human umbilical vein vascular endothelial cells, and analyzed by Transwell and tube formation assays. The expression of VEGF and FGF2 in oral lichen planus\u2010activated fibroblasts was detected, and the expression and phosphorylation levels of VEGFR2 and FAP in human umbilical vein vascular endothelial cells were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oral lichen planus subcutaneous tissues highly expressed Galectin\u20103, positively correlated with angiogenesis. Oral lichen planus\u2010activated fibroblasts expressed significantly higher Galectin\u20103 than NFs. Oral lichen planus\u2010activated fibroblasts overexpressing Galectin\u20103 enhanced the migration and tube\u2010forming capacity of co\u2010cultured human umbilical vein vascular endothelial cells. In oral lichen planus\u2010activated fibroblasts, 10\u2009\u03bcM\u2009GB1107 reduced the proliferation and migration capacity, decreased the expression of \u03b1\u2010SMA, FAP, VEGF, and FGF2, and inhibited the tube\u2010forming capacity and the expression of VEGFR2 phosphorylation and FAK in co\u2010cultured human umbilical vein vascular endothelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The upregulation of Galectin\u20103 expression in oral lichen planus is associated with angiogenesis, and the oral lichen planus\u2010activated fibroblasts promote human umbilical vein vascular endothelial cells migration and tube\u2010forming differentiation through VEGFR2\/FAP activation by Galectin\u20103.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13572","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T23:39:53Z","timestamp":1721950793000},"page":"511-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Galectin\u20103\u2010upregulated\n                    <scp>FAK<\/scp>\n                    promotes angiogenesis through oral lichen planus\u2010activated fibroblasts"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-1690","authenticated-orcid":false,"given":"Xiaoheng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinshen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010Sen University Guanghua School of Stomatology  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital, School of Stomatology, Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.200309"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.07.002"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"105","article-title":"Oral lichen planus: a disease or a spectrum of tissue reactions? 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