{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:17Z","timestamp":1772160737566,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018847","name":"Sel\u00e7uk University Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is well\u2010known that oral surgical procedures pose a high risk for medication\u2010related osteonecrosis of the jaw in patients taking bisphosphonates. Although some position papers and guidelines have been published with regard to its treatment, few studies have investigated prevention methods. This study investigates the effectiveness of methenolone enanthate, an anabolic steroid, for the prevention of medication\u2010related osteonecrosis of the jaw.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six Wistar rats were divided into three groups. Two experimental groups, Z and ZM, took zoledronic acid for 6\u2009weeks prior to extraction of the left maxillary first molar. The Group ZM also was given methenolone enanthate continuously for 1\u2009week before and 4\u2009weeks after the extraction. The control group was not given any medication. The rats were euthanized 5\u2009weeks after extraction. The extraction socket was evaluated clinically for bone exposure and histologically for inflammation, hyperemia, collagen fibers, epithelialization, number of osteoclasts, and empty lacunae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six rats died during the experimental research. The bone exposure rate, mean numbers of attached osteoclasts (in 40\u00d7 magnification), and empty lacunae (in 100\u00d7 magnification) were 0%, 4%, and 0.8% in Group C; 75%, 1%, and 8% in Group Z; and 10%, 2.1%, and 3% in Group ZM, respectively. Significant differences exist between all groups regarding the number of empty lacunae. There were significant differences between Group C\/ZM and Group Z in terms of bone exposure rate, inflammation, hyperemia, collagen fiber organization, and epithelialization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our tested preclinical model, methenolone enanthate has shown potential for preventing medication\u2010related osteonecrosis of the jaw.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13574","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T02:29:52Z","timestamp":1723084192000},"page":"530-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Methenolone Enanthate Efficacy in Preventing\n                    <scp>MRONJ<\/scp>\n                    : A Randomized Trial on Rats"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-4650","authenticated-orcid":false,"given":"G\u00f6khan","family":"G\u00fcrses","sequence":"first","affiliation":[{"name":"Dentistry Faculty, Department of Oral and Maxillofacial Surgery Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"Sur","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, Department of Histology Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziya\u00a0Ozan","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Private Practitioner"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muslu\u00a0Kaz\u0131m","family":"K\u00f6rez","sequence":"additional","affiliation":[{"name":"Medicine Faculty, Department of Biostatistics Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14887"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13556"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2021-0085"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-019-00621-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1612"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315247"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116184"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.05.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201601558"},{"issue":"68","key":"e_1_2_10_12_1","first-page":"287","article-title":"Effect of Honey on Healing Process of Extraction Socket in Rabbits","volume":"17","author":"Sarraf D. 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