{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:32:44Z","timestamp":1791361964945,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ameloblastoma is a locally destructive benign odontogenic tumor. While the neoplastic cells of conventional ameloblastoma can infiltrate the connective tissue and bone, in unicystic ameloblastoma the epithelium is encapsulated. The mechanisms driving ameloblastoma's bone resorption remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      RNA sequencing (RNA\u2010seq) was performed in a discovery cohort of conventional ameloblastoma, and pathway enrichment analysis was carried out. mRNA levels of\n                      <jats:italic>MMP13<\/jats:italic>\n                      , a gene associated with bone resorption, were assessed using RT\u2010qPCR in a larger cohort of conventional ameloblastoma and in unicystic ameloblastoma. Zymogram gels and the immunoexpression profile of collagenase 3 (encoded by\n                      <jats:italic>MMP13<\/jats:italic>\n                      gene) were evaluated as well.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Enriched pathways related to bone mineralization and upregulation of\n                      <jats:italic>MMP13<\/jats:italic>\n                      were observed in ameloblastomas. Collagenolytic activity of collagenase 3 was detected in the tumor lysates. Collagenase 3 immunopositivity was observed in ameloblastomatous epithelium infiltrating the fibrous capsule of unicystic ameloblastoma. At the tumor\u2013bone interface, collagenase 3 expression was detected in stromal cells, osteoblasts, and osteocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The results indicate a potential involvement of\n                      <jats:italic>MMP13<\/jats:italic>\n                      in ameloblastoma\u2010related bone resorption and progression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13577","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T02:34:23Z","timestamp":1724812463000},"page":"577-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>\n                      <i>MMP13<\/i>\n                    <\/scp>\n                    Expression and Activity Suggest Its Role in Bone Resorption in Ameloblastomas"],"prefix":"10.1111","volume":"53","author":[{"given":"Alline Teixeira","family":"Valeriano","sequence":"first","affiliation":[{"name":"Department of Pathology, Biological Sciences Institute Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais Santos","family":"Camara","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Sciences Institute Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-7434","authenticated-orcid":false,"given":"Vanessa de F\u00e1tima","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Sciences Institute Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte MG 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