{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:20Z","timestamp":1772160740382,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are inflammatory T\u2010cell mediated disorders of the oral mucosa (OM). Both are associated with an increased risk of oral squamous cell carcinoma, with OLL possibly having a higher rate of malignant transformation than OLP. Programmed death ligand 1 (PD\u2010L1) and indoleamine 2,3\u2010dioxygenase (IDO) are immunosuppressive molecules possessing inhibitory effect on T\u2010cells and have been implicated in carcinogenesis. The aim of this study was to examine the expression of PD\u2010L1 and IDO in OLP and OLL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010eight formalin\u2010fixed, paraffin\u2010embedded tissue samples diagnosed as OLP, compatible with OLP, or OLL were divided into OLP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939) or OLL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) groups based on both clinical and histopathological diagnostic criteria. Samples of healthy OM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) served as controls. Samples were immunohistochemically stained for PD\u2010L1 and IDO, and staining distribution and intensity were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Immunohistochemical expression of PD\u2010L1 was increased in the basal and intermediate layers of epithelium in OLP and in lamina propria in both OLP and OLL compared to controls. OLP and OLL showed increased expression of IDO in epithelium and lamina propria compared to controls. PD\u2010L1 staining intensity in the basal epithelial layer, and IDO staining intensity in lamina propria were increased in OLP compared to OLL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results indicate that the expression of PD\u2010L1 and IDO increases in OLP and OLL, suggesting that these molecules may play a role in the pathogenesis of both disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13582","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T23:41:19Z","timestamp":1727394079000},"page":"613-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of Programmed Death Ligand 1 and Indoleamine 2,3\u2010Dioxygenase in Oral Lichen Planus and Oral Lichenoid Lesions"],"prefix":"10.1111","volume":"53","author":[{"given":"Olli","family":"Kemppainen","sequence":"first","affiliation":[{"name":"Institute of Dentistry, School of Medicine, Faculty of Health Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Mathlin","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, School of Medicine, Faculty of Health Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Pasonen\u2010Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, School of Medicine, Faculty of Health Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Siponen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, School of Medicine, Faculty of Health Sciences University of Eastern Finland  Kuopio Finland"},{"name":"Department of Oral and Maxillofacial Diseases and Odontology Education Unit Kuopio University Hospital  Kuopio Finland"},{"name":"Research Unit of Translational Medicine, Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14142"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.04.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105188"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12996"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092537"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115611"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12521"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9717-3_1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.57334"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01035.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd2712"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502643"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.05.007"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9683-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.006"},{"key":"e_1_2_11_19_1","first-page":"194","article-title":"Importance 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