{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:30:28Z","timestamp":1778801428579,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucinous cells can be detected sporadically or may constitute the primary tumor component in salivary gland tumors, as observed in the intraductal papillary mucinous neoplasm (IPMN). This low\u2010grade tumor is composed of mucinous columnar cells organized into papillary cystic structures. The present study aimed to compare the mucous cells in IPMN with mucous cells present in mucoepidermoid carcinoma (MEC) and papillary cystadenoma (PC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Immunohistochemistry analysis was carried out to compare the mucous cells in IPMN with the sporadic mucous cells in MEC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and PC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicated that IPMN cells were positive for CK7, CK18, DOG1, and NKX3.1 and negative for CK14, SMA, and p63. The mucous cells in both MEC and PC were positive for CK7 and negative for CK18, SMA, DOG1, and NKX3.1. The positive expression of CK14 and p63 revealed the presence of basal cells both in PC, cystic areas of MEC, and normal mucous salivary glands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The immunohistochemical profile of IPMN closely resembles that of the mucous cells of the minor salivary glands yet differs from the mucous cells observed in MEC and PCX. This suggests that IPMN is probably derived from the transformation of secretory cells of the minor mucous salivary gland and has no rimming\/basal cells. For this reason, we propose that this tumor is designated as mucous acinic cell carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13588","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T22:54:39Z","timestamp":1731365679000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraductal Papillary Mucinous Neoplasm: New Insights Into Its Origin and Nomenclatures"],"prefix":"10.1111","volume":"54","author":[{"given":"Andresa Borges","family":"Soares","sequence":"first","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-9631","authenticated-orcid":false,"given":"Lucas Novaes","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana Vit\u00f3ria Batista Costa","family":"Melo","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio","family":"Passador Santos","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir Severina","family":"Freitas","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ney Soares","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Cavalcanti","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001080"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13990"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001688"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010022\u201001471\u20104"},{"key":"e_1_2_9_6_1","volume-title":"Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010023\u201001541\u20101"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896918813678"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102020\u2010235932"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14744\/eej.2022.29200"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000274"},{"issue":"5","key":"e_1_2_9_13_1","first-page":"685","article-title":"Mucinous Cystadenoma: A Rare Entity","volume":"10","author":"Rai S.","year":"2013","journal-title":"Dental Research Journal"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010015\u20103855\u20107"}],"container-title":["Journal of Oral Pathology &amp; 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