{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:27:19Z","timestamp":1789576039699,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is lack of knowledge on the utility of prognostic histopathologic characteristics in adenoid cystic carcinoma (ACC) of the head and neck. We evaluated the prognostic value of tumor and stroma\u2010related histopathologic features in ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 65 cases of ACC from minor and major salivary glands were included in this study. We evaluated tumor budding, tumor\u2010infiltrating lymphocytes (TILs), and tumor\u2010stroma ratio (TSR) in hematoxylin and eosin (HE) stained sections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stroma\u2010rich ACCs recurred more frequently (<jats:italic>p<\/jats:italic>\u2009=\u20090.029) during follow\u2010up and associated with distant metastasis (<jats:italic>p<\/jats:italic>\u2009=\u20090.038). In multivariable analysis, stroma\u2010rich tumors associated with poorer disease\u2010specific survival with a hazard ratio of 3.76 (95% CI 1.10\u201312.83, <jats:italic>p<\/jats:italic>\u2009=\u20090.034). ACCs commonly showed a low infiltration of TILs as 89% of the tumors was characterized by an immune desert pattern. Low infiltration of TILs associated significantly with increased tumor budding (<jats:italic>p<\/jats:italic>\u2009=\u20090.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adverse features of TSR and tumor budding are widely expressed in ACC, and stroma\u2010rich tumors are associated with poor prognosis. Low number of TILs in ACC tissue indicates a weak immune response by the host and illustrates the nature of ACC as a relentless malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13589","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T06:34:21Z","timestamp":1731306861000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stroma\u2010and Tumor\u2010Associated Predictive Features in\u00a0Salivary Gland Adenoid Cystic Carcinoma of the Head\u00a0and Neck"],"prefix":"10.1111","volume":"54","author":[{"given":"Aleksi","family":"Rytk\u00f6nen","sequence":"first","affiliation":[{"name":"Department of Pathology Oulu University Hospital  Oulu Finland"},{"name":"Department of Oral Pathology and Radiology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-6820","authenticated-orcid":false,"given":"Hanna K.","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Radiology University of Turku and Turku University Hospital  Turku Finland"},{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caj","family":"Haglund","sequence":"additional","affiliation":[{"name":"Research Programs Unit, Translational Cancer Medicine Program University of Helsinki  Helsinki Finland"},{"name":"Department of Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-7881","authenticated-orcid":false,"given":"Jaana","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Radiology University of Turku and Turku University Hospital  Turku Finland"},{"name":"Research Programs Unit, Translational Cancer Medicine Program University of Helsinki  Helsinki Finland"},{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alhadi","family":"Almangush","sequence":"additional","affiliation":[{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Institute of Biomedicine, Pathology, University of Turku and Turku University Central Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilmo","family":"Leivo","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Pathology, University of Turku and Turku University Central Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105945"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/COC.0b013e3181d26d45","article-title":"Determinants and Patterns of Survival in Adenoid Cystic Carcinoma of the Head and Neck, Including an Analysis of Adjuvant Radiation Therapy","volume":"34","author":"Lloyd S.","year":"2011","journal-title":"American Journal of Clinical Oncology: Cancer Clinical Trials"},{"key":"e_1_2_10_4_1","unstructured":"A. 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R.Grandis et\u00a0al. \u201cWHO Classification of Head and Neck Tumours\u2010WHO\/IARC Classification of Tumours \u201d(2017)."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6172"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0073-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25872"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0422-y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061558"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08222-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041111"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29050263"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12135"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110873"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061383"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1760-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2163-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27583"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000161"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu450"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2408-z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-022-06587-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0102-9"},{"key":"e_1_2_10_24_1","first-page":"3683","article-title":"Revisiting Epithelial\u2010To\u2010Mesenchymal Transition Through Adenoid Cystic Carcinoma","volume":"32","author":"Siu A.","year":"2012","journal-title":"Anticancer Research"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13406"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105777"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07884-3"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T02:06:15Z","timestamp":1736820375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jop.13589"],"URL":"https:\/\/doi.org\/10.1111\/jop.13589","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}